Yoshihiko Ikeguchi
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Explore the profile of Yoshihiko Ikeguchi including associated specialties, affiliations and a list of published articles.
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16
Citations
424
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Recent Articles
1.
Zhang Z, Martiny V, Lagorce D, Ikeguchi Y, Alexov E, Miteva M
PLoS One
. 2014 Oct;
9(10):e110884.
PMID: 25340632
Snyder-Robinson Syndrome (SRS) is a rare mental retardation disorder which is caused by the malfunctioning of an enzyme, the spermine synthase (SMS), which functions as a homo-dimer. The malfunctioning of...
2.
Zhang Z, Zheng Y, Petukh M, Pegg A, Ikeguchi Y, Alexov E
PLoS Comput Biol
. 2013 Mar;
9(2):e1002924.
PMID: 23468611
Spermine synthase (SMS) is an enzyme which function is to convert spermidine into spermine. It was shown that gene defects resulting in amino acid changes of the wild type SMS...
3.
Zhang Z, Witham S, Petukh M, Moroy G, Miteva M, Ikeguchi Y, et al.
J Am Med Inform Assoc
. 2013 Feb;
20(4):643-51.
PMID: 23408511
Background And Significance: Intellectual disability is a condition characterized by significant limitations in cognitive abilities and social/behavioral adaptive skills and is an important reason for pediatric, neurologic, and genetic referrals....
4.
Yamazaki K, Ikeguchi Y, Niwa T, Hayashi K, Iwaki T, Ishii I, et al.
Anal Sci
. 2012 Jun;
28(6):621-4.
PMID: 22729051
Polyamines such as spermidine (Spd) and spermine (Spm), produced by aminopropyltransferase (Apt), play roles in cell growth and differentiation. A sensitive and simple fluorometric high-performance liquid chromatographic determination for Apt...
5.
Ishii I, Ikeguchi Y, Mano H, Wada M, Pegg A, Shirahata A
Amino Acids
. 2011 Aug;
42(2-3):619-26.
PMID: 21809076
Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine...
6.
Saiki R, Park H, Ishii I, Yoshida M, Nishimura K, Toida T, et al.
Biochem Biophys Res Commun
. 2010 Dec;
404(4):1044-9.
PMID: 21187074
Although it is thought that the major factor responsible for cell damage is reactive oxygen species (ROS), our recent studies have shown that acrolein is more toxic than ROS. Thus,...
7.
Wu H, Min J, Zeng H, McCloskey D, Ikeguchi Y, Loppnau P, et al.
J Biol Chem
. 2008 Mar;
283(23):16135-46.
PMID: 18367445
The crystal structures of two ternary complexes of human spermine synthase (EC 2.5.1.22), one with 5'-methylthioadenosine and spermidine and the other with 5'-methylthioadenosine and spermine, have been solved. They show...
8.
Ito T, Sugita Y, Takao K, Ikeguchi Y, Shirahata A
Biol Pharm Bull
. 2007 Oct;
30(10):1838-43.
PMID: 17917247
We recently reported that C-terminal polyamine modification occurs when proteins are digested with trypsin in the presence of polyamine [Biochem. Biophys. Res. Commun., 356, 159-162 (2007)]. In the present study,...
9.
Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, et al.
Biochemistry
. 2007 Jun;
46(28):8331-9.
PMID: 17585781
Aminopropyltransferases transfer aminopropyl groups from decarboxylated S-adenosylmethionine to amine acceptors, forming polyamines. Structural and biochemical studies have been carried out with the human spermidine synthase, which is highly specific for...
10.
Ito T, Sugita Y, Ikeguchi Y, Shirahata A
Biochem Biophys Res Commun
. 2007 Mar;
356(1):159-62.
PMID: 17346676
The effect of polyamines on the digestion of proteins by serine proteases was examined. Based on the mechanism of action of serine proteases, it was anticipated that nucleophilic functionalities such...