Yoshihiko Ikeguchi
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Explore the profile of Yoshihiko Ikeguchi including associated specialties, affiliations and a list of published articles.
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16
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424
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Recent Articles
11.
Ikeguchi Y, Bewley M, Pegg A
J Biochem
. 2006 Jan;
139(1):1-9.
PMID: 16428313
Aminopropyltransferases use decarboxylated S-adenosylmethionine as an aminopropyl donor and an amine acceptor to form polyamines. This review covers their structure, mechanism of action, inhibition, regulation and function. The best known...
12.
Wang X, Ikeguchi Y, McCloskey D, Nelson P, Pegg A
J Biol Chem
. 2004 Oct;
279(49):51370-5.
PMID: 15459188
Spermidine is essential for viability in eukaryotes but the importance of the longer polyamine spermine has not been established. Spermine is formed from spermidine by the action of spermine synthase,...
13.
Ikeguchi Y, Wang X, McCloskey D, Coleman C, Nelson P, Hu G, et al.
Biochem J
. 2004 Apr;
381(Pt 3):701-7.
PMID: 15104536
A widespread increase in SpmS (spermine synthase) activity has been produced in transgenic mice using a construct in which the human SpmS cDNA was placed under the control of a...
14.
Cason A, Ikeguchi Y, Skinner C, Wood T, Holden K, Lubs H, et al.
Eur J Hum Genet
. 2003 Sep;
11(12):937-44.
PMID: 14508504
Polyamines (putrescine, spermidine, spermine) are ubiquitous, simple molecules that interact with a variety of other molecules in the cell, including nucleic acids, phospholipids and proteins. Various studies indicate that polyamines...
15.
Ikeguchi Y, Mackintosh C, McCloskey D, Pegg A
Biochem J
. 2003 May;
373(Pt 3):885-92.
PMID: 12737625
The role of spermine in the sensitivity of cells to various established and experimental anti-tumour agents was examined, using paired cell lines that possess or lack spermine synthase. All spermine-synthase-deficient...
16.
Korolev S, Ikeguchi Y, Skarina T, Beasley S, Arrowsmith C, Edwards A, et al.
Nat Struct Biol
. 2001 Dec;
9(1):27-31.
PMID: 11731804
Polyamines are essential in all branches of life. Spermidine synthase (putrescine aminopropyltransferase, PAPT) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine. The crystal structure of the PAPT from Thermotoga maritima...