Yoon-Chi Han
Overview
Explore the profile of Yoon-Chi Han including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
1531
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0
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Recent Articles
1.
Han Y, Kahler J, Piche-Nicholas N, Hu W, Thibault S, Jiang F, et al.
Clin Cancer Res
. 2020 Nov;
27(2):622-631.
PMID: 33148666
Purpose: Mortality due to acute myeloid leukemia (AML) remains high, and the management of relapsed or refractory AML continues to be therapeutically challenging. The reapproval of Mylotarg, an anti-CD33-calicheamicin antibody-drug...
2.
Corrigendum: In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Maddalo D, Manchado E, Concepcion C, Bonetti C, Vidigal J, Han Y, et al.
Nature
. 2015 Jun;
524(7566):502.
PMID: 26106864
No abstract available.
3.
Han Y, Vidigal J, Mu P, Yao E, Singh I, Gonzalez A, et al.
Nat Genet
. 2015 Jun;
47(7):766-75.
PMID: 26029871
Polycistronic microRNA (miRNA) clusters are a common feature of vertebrate genomes. The coordinated expression of miRNAs belonging to different seed families from a single transcriptional unit suggests functional cooperation, but...
4.
Maddalo D, Manchado E, Concepcion C, Bonetti C, Vidigal J, Han Y, et al.
Nature
. 2014 Oct;
516(7531):423-7.
PMID: 25337876
Chromosomal rearrangements have a central role in the pathogenesis of human cancers and often result in the expression of therapeutically actionable gene fusions. A recently discovered example is a fusion...
5.
6.
Concepcion C, Han Y, Mu P, Bonetti C, Yao E, DAndrea A, et al.
PLoS Genet
. 2012 Jul;
8(7):e1002797.
PMID: 22844244
MicroRNAs belonging to the miR-34 family have been proposed as critical modulators of the p53 pathway and potential tumor suppressors in human cancers. To formally test these hypotheses, we have...
7.
Agostini M, Tucci P, Steinert J, Shalom-Feuerstein R, Rouleau M, Aberdam D, et al.
Proc Natl Acad Sci U S A
. 2011 Dec;
108(52):21099-104.
PMID: 22160706
The p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, we have shown that p73 drives the...
8.
Lal A, Thomas M, Altschuler G, Navarro F, ODay E, Li X, et al.
PLoS Genet
. 2011 Nov;
7(11):e1002363.
PMID: 22102825
A simple biochemical method to isolate mRNAs pulled down with a transfected, biotinylated microRNA was used to identify direct target genes of miR-34a, a tumor suppressor gene. The method reidentified...
9.
Han Y, Park C, Bhagat G, Zhang J, Wang Y, Fan J, et al.
J Exp Med
. 2010 Mar;
207(3):475-89.
PMID: 20212066
The function of microRNAs (miRNAs) in hematopoietic stem cells (HSCs), committed progenitors, and leukemia stem cells (LSCs) is poorly understood. We show that miR-29a is highly expressed in HSC and...
10.
Mu P, Han Y, Betel D, Yao E, Squatrito M, Ogrodowski P, et al.
Genes Dev
. 2009 Dec;
23(24):2806-11.
PMID: 20008931
The miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA). miR-17 approximately 92 is a direct transcriptional...