Yong-Gang Chang
Overview
Explore the profile of Yong-Gang Chang including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
605
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Recent Articles
1.
Bayly-Jones C, Lupton C, DAndrea L, Chang Y, Jones G, Steele J, et al.
Sci Adv
. 2024 Nov;
10(47):eadr5807.
PMID: 39565846
Tuberous sclerosis complex (TSC) is targeted to the lysosomal membrane, where it hydrolyzes RAS homolog-mTORC1 binding (RHEB) from its GTP-bound to GDP-bound state, inhibiting mechanistic target of rapamycin complex 1...
2.
Bayly-Jones C, Lupton C, Keen A, Dong S, Mastos C, Luo W, et al.
Nature
. 2024 Oct;
634(8036):1238-1244.
PMID: 39358511
Lysosomes have crucial roles in regulating eukaryotic metabolism and cell growth by acting as signalling platforms to sense and respond to changes in nutrient and energy availability. LYCHOS (GPR155) is...
3.
Chavan A, Heisler J, Chang Y, Golden S, Partch C, LiWang A
Biopolymers
. 2023 Jul;
115(2):e23559.
PMID: 37421636
Circadian clocks are intracellular systems that orchestrate metabolic processes in anticipation of sunrise and sunset by providing an internal representation of local time. Because the ~24-h metabolic rhythms they produce...
4.
Chang Y, Lupton C, Bayly-Jones C, Keen A, DAndrea L, Lucato C, et al.
Nat Struct Mol Biol
. 2022 Jul;
29(8):767-773.
PMID: 35864164
P-Rex (PI(3,4,5)P-dependent Rac exchanger) guanine nucleotide exchange factors potently activate Rho GTPases. P-Rex guanine nucleotide exchange factors are autoinhibited, synergistically activated by Gβγ and PI(3,4,5)P binding and dysregulated in cancer....
5.
Chow G, Chavan A, Heisler J, Chang Y, Zhang N, LiWang A, et al.
J Am Chem Soc
. 2022 Jan;
144(1):184-194.
PMID: 34979080
As the only circadian oscillator that can be reconstituted with its constituent proteins KaiA, KaiB, and KaiC using ATP as an energy source, the cyanobacterial circadian oscillator serves as a...
6.
DAndrea L, Lucato C, Marquez E, Chang Y, Civciristov S, Mastos C, et al.
Sci Signal
. 2021 May;
14(681).
PMID: 33947796
The dual-specificity phosphatase PTEN functions as a tumor suppressor by hydrolyzing PI(3,4,5)P to PI(4,5)P to inhibit PI3K-AKT signaling and cellular proliferation. P-Rex2 is a guanine nucleotide exchange factor for Rho...
7.
Heisler J, Chavan A, Chang Y, LiWang A
Methods Mol Biol
. 2020 Dec;
2130:3-18.
PMID: 33284432
Stochastic diffusion of a solution of fluorophores after photoselection reduces the polarization of emission, or fluorescence anisotropy. Because this randomization process is slower for larger molecules, fluorescence anisotropy is effective...
8.
Zhang N, Chang Y, Tseng R, Ovchinnikov S, Schwarz R, LiWang A
Protein Sci
. 2020 Sep;
29(11):2274-2280.
PMID: 32949024
Biofilms are accumulations of microorganisms embedded in extracellular matrices that protect against external factors and stressful environments. Cyanobacterial biofilms are ubiquitous and have potential for treatment of wastewater and sustainable...
9.
Chow G, Chavan A, Heisler J, Chang Y, LiWang A, Britt R
Biochemistry
. 2020 May;
59(26):2387-2400.
PMID: 32453554
The cyanobacterial circadian clock in consists of three proteins, KaiA, KaiB, and KaiC. KaiA and KaiB rhythmically interact with KaiC to generate stable oscillations of KaiC phosphorylation with a period...
10.
Heisler J, Chavan A, Chang Y, LiWang A
Methods Protoc
. 2019 Jun;
2(2).
PMID: 31164621
Uniquely, the circadian clock of cyanobacteria can be reconstructed outside the complex milieu of live cells, greatly simplifying the investigation of a functioning biological chronometer. The core oscillator component is...