Yong-Gang Chang
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Explore the profile of Yong-Gang Chang including associated specialties, affiliations and a list of published articles.
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27
Citations
605
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Recent Articles
11.
Welkie D, Rubin B, Chang Y, Diamond S, Rifkin S, LiWang A, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(30):E7174-E7183.
PMID: 29991601
The recurrent pattern of light and darkness generated by Earth's axial rotation has profoundly influenced the evolution of organisms, selecting for both biological mechanisms that respond acutely to environmental changes...
12.
Tseng R, Goularte N, Chavan A, Luu J, Cohen S, Chang Y, et al.
Science
. 2017 Mar;
355(6330):1174-1180.
PMID: 28302851
Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational clock consisting of KaiA,...
13.
Chang Y, Cohen S, Phong C, Myers W, Kim Y, Tseng R, et al.
Science
. 2015 Jun;
349(6245):324-8.
PMID: 26113641
Organisms are adapted to the relentless cycles of day and night, because they evolved timekeeping systems called circadian clocks, which regulate biological activities with ~24-hour rhythms. The clock of cyanobacteria...
14.
Tseng R, Chang Y, Bravo I, Latham R, Chaudhary A, Kuo N, et al.
J Mol Biol
. 2013 Oct;
426(2):389-402.
PMID: 24112939
The circadian oscillator of cyanobacteria is composed of only three proteins, KaiA, KaiB, and KaiC. Together, they generate an autonomous ~24-h biochemical rhythm of phosphorylation of KaiC. KaiA stimulates KaiC...
15.
Chang Y, Tseng R, Kuo N, LiWang A
Integr Comp Biol
. 2013 May;
53(1):93-102.
PMID: 23667047
The most well-understood circadian clock at the level of molecular mechanisms is that of cyanobacteria. This overview is on how solution-state nuclear magnetic resonance (NMR) spectroscopy has contributed to this...
16.
Chang Y, Tseng R, Kuo N, LiWang A
Proc Natl Acad Sci U S A
. 2012 Sep;
109(42):16847-51.
PMID: 22967510
The oscillator of the circadian clock of cyanobacteria is composed of three proteins, KaiA, KaiB, and KaiC, which together generate a self-sustained ∼24-h rhythm of phosphorylation of KaiC. The mechanism...
17.
Chang Y, Kuo N, Tseng R, LiWang A
Proc Natl Acad Sci U S A
. 2011 Jul;
108(35):14431-6.
PMID: 21788479
In the cyanobacterial circadian oscillator, KaiA and KaiB alternately stimulate autophosphorylation and autodephosphorylation of KaiC with a periodicity of approximately 24 h. KaiA activates autophosphorylation by selectively capturing the A...
18.
Wood T, Bridwell-Rabb J, Kim Y, Gao T, Chang Y, LiWang A, et al.
Proc Natl Acad Sci U S A
. 2010 Mar;
107(13):5804-9.
PMID: 20231482
The circadian rhythms exhibited in the cyanobacterium Synechococcus elongatus are generated by an oscillator comprised of the proteins KaiA, KaiB, and KaiC. An external signal that commonly affects the circadian...
19.
Zhou Z, Gao H, Zhou C, Chang Y, Hong J, Song A, et al.
Protein Sci
. 2008 Jul;
17(10):1805-14.
PMID: 18596201
The Cbl proteins, RING-type E3 ubiquitin ligases, are responsible for ubiquitinating the activated tyrosine kinases and targeting them for degradation. Both c-Cbl and Cbl-b have a UBA (ubiquitin-associated) domain at...
20.
Chang Y, Yan X, Xie Y, Gao X, Song A, Zhang D, et al.
J Biol Chem
. 2008 Mar;
283(19):13370-7.
PMID: 18356159
ISG15 (interferon-stimulated gene 15) is a novel ubiquitin-like (UbL) modifier with two UbL domains in its architecture. We investigated different roles for the two UbL domains in protein modification by...