Yasuhiro Yoshimura
Overview
Explore the profile of Yasuhiro Yoshimura including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
419
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Recent Articles
1.
Muto Y, Yoshimura Y, Wu H, Chang-Panesso M, Ledru N, Woodward O, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(43):e2410830121.
PMID: 39405347
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and causes significant morbidity, ultimately leading to kidney failure. PKD pathogenesis is characterized by complex and dynamic...
2.
Muto Y, Dixon E, Yoshimura Y, Ledru N, Kirita Y, Wu H, et al.
Sci Adv
. 2024 Aug;
10(32):eado2849.
PMID: 39110788
Acute kidney injury (AKI) causes epithelial damage followed by subsequent repair. While successful repair restores kidney function, this process is often incomplete and can lead to chronic kidney disease (CKD)...
3.
Noonan M, Muto Y, Yoshimura Y, Leckie-Harre A, Wu H, Kalinichenko V, et al.
JCI Insight
. 2024 Jun;
9(15).
PMID: 38916959
Acute kidney injury (AKI) strongly upregulates the transcription factor Foxm1 in the proximal tubule in vivo, and Foxm1 drives epithelial proliferation in vitro. Here, we report that deletion of Foxm1...
4.
Muto Y, Yoshimura Y, Wu H, Chang-Panesso M, Ledru N, Woodward O, et al.
bioRxiv
. 2024 Jun;
PMID: 38854144
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and causes significant morbidity, ultimately leading to end-stage kidney disease. PKD pathogenesis is characterized by complex and...
5.
Bradford S, Wu H, Kirita Y, Chen C, Malvin N, Yoshimura Y, et al.
Am J Physiol Renal Physiol
. 2024 Mar;
326(5):F827-F838.
PMID: 38482555
In the aftermath of acute kidney injury (AKI), surviving proximal tubule epithelia repopulate injured tubules to promote repair. However, a portion of cells fail to repair [termed failed-repair proximal tubule...
6.
Wu H, Dixon E, Xuanyuan Q, Guo J, Yoshimura Y, Debashish C, et al.
Nat Commun
. 2024 Feb;
15(1):1396.
PMID: 38360882
Emerging spatially resolved transcriptomics technologies allow for the measurement of gene expression in situ at cellular resolution. We apply direct RNA hybridization-based in situ sequencing (dRNA HybISS, Cartana part of...
7.
Ledru N, Wilson P, Muto Y, Yoshimura Y, Wu H, Li D, et al.
Nat Commun
. 2024 Feb;
15(1):1291.
PMID: 38347009
Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and assumes a proinflammatory and...
8.
Muto Y, Dixon E, Yoshimura Y, Ledru N, Kirita Y, Wu H, et al.
bioRxiv
. 2024 Feb;
PMID: 38328130
Acute kidney injury (AKI) causes epithelial damage followed by subsequent repair. While successful repair restores kidney function, this process is often incomplete and can lead to chronic kidney disease (CKD)...
9.
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Wilson P, Verma A, Yoshimura Y, Muto Y, Li H, Malvin N, et al.
Genome Biol
. 2024 Jan;
25(1):36.
PMID: 38287344
Background: Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY is present...
10.
Yoshimura Y, Muto Y, Omachi K, Miner J, Humphreys B
J Am Soc Nephrol
. 2023 Jul;
34(10):1672-1686.
PMID: 37488681
Significance Statement: HNF4 genes promote proximal tubule differentiation in mice, but their function in human nephrogenesis is not fully defined. This study uses human pluripotent stem cell (PSC)-derived kidney organoids...