Y Zenmei Ohkubo
Overview
Explore the profile of Y Zenmei Ohkubo including associated specialties, affiliations and a list of published articles.
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13
Citations
332
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Recent Articles
1.
Madsen J, Ohkubo Y
PLoS Comput Biol
. 2024 Jul;
20(7):e1011421.
PMID: 38976709
Membrane binding is a crucial mechanism for many proteins, but understanding the specific interactions between proteins and membranes remains a challenging endeavor. Coagulation factor Va (FVa) is a large protein...
2.
Ohkubo Y, Radulovic P, Kahira A, Madsen J
Curr Res Struct Biol
. 2024 May;
7:100149.
PMID: 38766652
Anchoring of coagulation factors to anionic regions of the membrane involves the C2 domain as a key player. The rate of enzymatic reactions of the coagulation factors is increased by...
3.
Ohkubo Y, Madsen J
Thromb Haemost
. 2021 Jul;
121(9):1122-1137.
PMID: 34214998
In the life sciences, including hemostasis and thrombosis, methods of structural biology have become indispensable tools for shedding light on underlying mechanisms that govern complex biological processes. Advancements of the...
4.
Madsen J, Ohkubo Y, Peters G, Faber J, Tajkhorshid E, Olsen O
Biochemistry
. 2015 Sep;
54(39):6123-31.
PMID: 26346528
A recently developed membrane-mimetic model was applied to study membrane interaction and binding of the two anchoring C2-like discoidin domains of human coagulation factor VIIIa (FVIIIa), the C1 and C2...
5.
Ohkubo Y, Pogorelov T, Arcario M, Christensen G, Tajkhorshid E
Biophys J
. 2012 Jul;
102(9):2130-9.
PMID: 22824277
Characterizing atomic details of membrane binding of peripheral membrane proteins by molecular dynamics (MD) has been significantly hindered by the slow dynamics of membrane reorganization associated with the phenomena. To...
6.
Tavoosi N, Davis-Harrison R, Pogorelov T, Ohkubo Y, Arcario M, Clay M, et al.
J Biol Chem
. 2011 May;
286(26):23247-53.
PMID: 21561861
Many regulatory processes in biology involve reversible association of proteins with membranes. Clotting proteins bind to phosphatidylserine (PS) on cell surfaces, but a clear picture of this interaction has yet...
7.
Arcario M, Ohkubo Y, Tajkhorshid E
J Phys Chem B
. 2011 May;
115(21):7029-37.
PMID: 21561114
Membrane binding of peripheral proteins, mediated by specialized anchoring domains, is a crucial step for their biological function. Computational studies of membrane insertion, however, have proven challenging and largely inaccessible,...
8.
Boettcher J, Davis-Harrison R, Clay M, Nieuwkoop A, Ohkubo Y, Tajkhorshid E, et al.
Biochemistry
. 2011 Feb;
50(12):2264-73.
PMID: 21294564
Membranes play key regulatory roles in biological processes, with bilayer composition exerting marked effects on binding affinities and catalytic activities of a number of membrane-associated proteins. In particular, proteins involved...
9.
Morrissey J, Davis-Harrison R, Tavoosi N, Ke K, Pureza V, Boettcher J, et al.
Thromb Res
. 2010 Feb;
125 Suppl 1:S23-5.
PMID: 20129649
Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how...
10.
Morrissey J, Pureza V, Davis-Harrison R, Sligar S, Ohkubo Y, Tajkhorshid E
Thromb Res
. 2008 Aug;
122 Suppl 1:S23-6.
PMID: 18691494
Blood clotting reactions, such as those catalyzed by the tissue factor:factor VIIa complex (TF:FVIIa), assemble on membrane surfaces containing anionic phospholipids such as phosphatidylserine (PS). In fact, membrane binding is...