Y A Lazebnik
Overview
Explore the profile of Y A Lazebnik including associated specialties, affiliations and a list of published articles.
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14
Citations
2291
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Recent Articles
1.
Soengas M, Capodieci P, Polsky D, Mora J, Esteller M, McCombie R, et al.
Nature
. 2001 Feb;
409(6817):207-11.
PMID: 11196646
Metastatic melanoma is a deadly cancer that fails to respond to conventional chemotherapy and is poorly understood at the molecular level. p53 mutations often occur in aggressive and chemoresistant cancers...
2.
Svingen P, Karp J, Krajewski S, Mesner Jr P, Gore S, Burke P, et al.
Blood
. 2000 Nov;
96(12):3922-31.
PMID: 11090079
Recent studies have suggested that variations in levels of caspases, a family of intracellular cysteine proteases, can profoundly affect the ability of cells to undergo apoptosis. In this study, immunoblotting...
3.
Duelli D, Lazebnik Y
Nat Cell Biol
. 2000 Nov;
2(11):859-62.
PMID: 11056544
Oncogenes that promote cell-cycle progression also sensitize cells to agents that induce apoptosis, possibly by inactivating inhibitors that ordinarily provide protection against cell death. Here we show that the adenoviral...
4.
Kirsch D, Doseff A, Chau B, Lim D, de Souza-Pinto N, Hansford R, et al.
J Biol Chem
. 1999 Jul;
274(30):21155-61.
PMID: 10409669
Caspases are cysteine proteases that mediate apoptosis by proteolysis of specific substrates. Although many caspase substrates have been identified, for most substrates the physiologic caspase(s) required for cleavage is unknown....
5.
Fearnhead H, Rodriguez J, Govek E, Guo W, Kobayashi R, Hannon G, et al.
Proc Natl Acad Sci U S A
. 1998 Nov;
95(23):13664-9.
PMID: 9811857
Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected...
6.
Fearnhead H, McCurrach M, ONeill J, Zhang K, Lowe S, Lazebnik Y
Genes Dev
. 1997 May;
11(10):1266-76.
PMID: 9171371
Many genotoxic agents kill tumor cells by inducing apoptosis; hence, mutations that suppress apoptosis produce resistance to chemotherapy. Although directly activating the apoptotic machinery may bypass these mutations, how to...
7.
Takahashi A, Alnemri E, Lazebnik Y, Fernandes-Alnemri T, Litwack G, Moir R, et al.
Proc Natl Acad Sci U S A
. 1996 Aug;
93(16):8395-400.
PMID: 8710882
Although proteases related to the interleukin 1 beta-converting enzyme (ICE) are known to be essential for apoptotic execution, the number of enzymes involved, their substrate specificities, and their specific roles...
8.
Lazebnik Y, Takahashi A, Moir R, Goldman R, Poirier G, Kaufmann S, et al.
Proc Natl Acad Sci U S A
. 1995 Sep;
92(20):9042-6.
PMID: 7568069
Although specific proteinases play a critical role in the active phase of apoptosis, their substrates are largely unknown. We previously identified poly(ADP-ribose) polymerase (PARP) as an apoptosis-associated substrate for proteinase(s)...
9.
Nicholson D, Ali A, Thornberry N, Vaillancourt J, Ding C, Gallant M, et al.
Nature
. 1995 Jul;
376(6535):37-43.
PMID: 7596430
The protease responsible for the cleavage of poly(ADP-ribose) polymerase and necessary for apoptosis has been purified and characterized. This enzyme, named apopain, is composed of two subunits of relative molecular...
10.
Lazebnik Y, Takahashi A, Poirier G, Kaufmann S, Earnshaw W
J Cell Sci Suppl
. 1995 Jan;
19:41-9.
PMID: 8655646
Apoptotic cell death is characterized by a dramatic morphological transformation during which apparently healthy cells suddenly initiate a comprehensive program of motility changes and degradative activities that culminates in disassembly...