H O Fearnhead
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Explore the profile of H O Fearnhead including associated specialties, affiliations and a list of published articles.
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15
Citations
264
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Recent Articles
1.
Elliman S, Howley B, Mehta D, Fearnhead H, Kemp D, Barkley L
Oncogenesis
. 2014 Aug;
3:e113.
PMID: 25111862
MicroRNAs (miRNAs) are deregulated in cancer and have been shown to exhibit both oncogenic and tumor suppressive functions. Although the functional effects of several miRNAs have been elucidated, those of...
2.
Fabian Z, Fearnhead H
Biochem Biophys Res Commun
. 2010 Apr;
395(4):458-64.
PMID: 20381455
The serine protease inhibitor N-alpha-tosyl-epsilon-phenylalanyl chloromethyl ketone (TPCK) has been long used in studies of cellular processes including apoptosis. Depending on the experimental conditions, TPCK either induces or inhibits changes...
3.
Fabian Z, OBrien P, Pajecka K, Fearnhead H
Apoptosis
. 2009 Aug;
14(10):1154-64.
PMID: 19653099
N-alpha-Tosyl-L: -phenylalanyl chloromethyl ketone (TPCK) is an affinity label for chymotrypsin-like proteases and has been extensively used as an experimental tool in apoptosis research to probe the role of proteases...
4.
Howley B, Fearnhead H
J Cell Mol Med
. 2008 Feb;
12(5A):1502-16.
PMID: 18298652
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation;...
5.
Malet G, Martin A, Orzaez M, Vicent M, Masip I, Sanclimens G, et al.
Cell Death Differ
. 2005 Dec;
13(9):1523-32.
PMID: 16341125
Apoptosis is a biological process relevant to human disease states that is strongly regulated through protein-protein complex formation. These complexes represent interesting points of chemical intervention for the development of...
6.
Davydov I, Woods D, Safiran Y, Oberoi P, Fearnhead H, Fang S, et al.
J Biomol Screen
. 2005 Jan;
9(8):695-703.
PMID: 15634796
An assay for the autoubiquitination activity of the E3 ligase HDM2 (Mdm2) was developed and adapted to a high-throughput format to identify inhibitors of this activity. The assay can also...
7.
8.
Richter B, S Mir S, Eiben L, Lewis J, Reffey S, Frattini A, et al.
Mol Cell Biol
. 2001 Jun;
21(13):4292-301.
PMID: 11390657
Inhibitor of apoptosis protein (IAP)-like protein-1 (ILP-1) (also known as X-linked IAP [XIAP] and mammalian IAP homolog A [MIHA]) is a potent inhibitor of apoptosis and exerts its effects, at...
9.
Fearnhead H, Rodriguez J, Govek E, Guo W, Kobayashi R, Hannon G, et al.
Proc Natl Acad Sci U S A
. 1998 Nov;
95(23):13664-9.
PMID: 9811857
Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected...
10.
Fearnhead H, McCurrach M, ONeill J, Zhang K, Lowe S, Lazebnik Y
Genes Dev
. 1997 May;
11(10):1266-76.
PMID: 9171371
Many genotoxic agents kill tumor cells by inducing apoptosis; hence, mutations that suppress apoptosis produce resistance to chemotherapy. Although directly activating the apoptotic machinery may bypass these mutations, how to...