W C Earnshaw
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Explore the profile of W C Earnshaw including associated specialties, affiliations and a list of published articles.
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159
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9632
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Recent Articles
1.
Earnshaw W, Allshire R, Black B, Bloom K, Brinkley B, Brown W, et al.
Chromosome Res
. 2013 Apr;
21(2):101-6.
PMID: 23580138
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has...
2.
Ohta S, Bukowski-Wills J, Wood L, de Lima Alves F, Chen Z, Rappsilber J, et al.
Cold Spring Harb Symp Quant Biol
. 2011 Feb;
75:433-8.
PMID: 21289047
Despite many decades of study, mitotic chromosomes remain poorly characterized with respect to their structure and composition. Here, we have purified mitotic chromosomes from nocodazole-treated chicken DT40 cells. These chromosomes...
3.
Vagnarelli P, Ribeiro S, Earnshaw W
FEBS Lett
. 2008 Apr;
582(14):1950-9.
PMID: 18435926
The centromere is a specialised region of the eukaryotic chromosome that directs the equal segregation of sister chromatids into two daughter cells during mitosis. In mitosis, the kinetochores mediate (1)...
4.
Kaufmann S, Kottke T, Martins L, Henzing A, Earnshaw W
Curr Protoc Cell Biol
. 2008 Jan;
Chapter 18:Unit 18.2.
PMID: 18228341
This unit describes three methods for the detection of caspase activation as cells undergo apoptosis. Simple and relatively quantitative enzymatic assays are provided using suitable substrates. Because the various low-molecular-weight...
5.
Loegering D, Ruchaud S, Earnshaw W, Kaufmann S
Cell Death Differ
. 2005 Nov;
13(2):346-7.
PMID: 16294214
No abstract available.
6.
Morrison C, Vagnarelli P, Sonoda E, Takeda S, Earnshaw W
Biochem Soc Trans
. 2003 Jan;
31(Pt 1):263-5.
PMID: 12546698
For successful eukaryotic mitosis, sister chromatid pairs remain linked after replication until their kinetochores have been attached to opposite spindle poles by microtubules. This linkage is broken at the metaphase-anaphase...
7.
Sonoda E, Matsusaka T, Morrison C, Vagnarelli P, Hoshi O, Ushiki T, et al.
Dev Cell
. 2001 Dec;
1(6):759-70.
PMID: 11740938
Proteolytic cleavage of the cohesin subunit Scc1 is a consistent feature of anaphase onset, although temporal differences exist between eukaryotes in cohesin loss from chromosome arms, as distinct from centromeres....
8.
Vagnarelli P, Earnshaw W
Chromosoma
. 2001 Dec;
110(6):393-401.
PMID: 11734997
Inactive centromeres of stable dicentric chromosomes provide a unique opportunity to examine the resolution of sister chromatid cohesion in mitosis. Here we show for the first time that inactive centromeres...
9.
Van Hooser A, Ouspenski I, Gregson H, STARR D, Yen T, Goldberg M, et al.
J Cell Sci
. 2001 Oct;
114(Pt 19):3529-42.
PMID: 11682612
The mechanisms that specify precisely where mammalian kinetochores form within arrays of centromeric heterochromatin remain largely unknown. Localization of CENP-A exclusively beneath kinetochore plates suggests that this distinctive histone might...
10.
Samejima K, Tone S, Earnshaw W
J Biol Chem
. 2001 Sep;
276(48):45427-32.
PMID: 11577114
DNA degradation during apoptotic execution generally occurs at two levels: early as high molecular weight (HMW) fragments and later on as oligonucleosomal fragments. Two nucleases, CAD/CPAN/DFF40 and endonuclease G, can...