Xianzhong Wu
Overview
Explore the profile of Xianzhong Wu including associated specialties, affiliations and a list of published articles.
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24
Citations
1543
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Recent Articles
1.
Wu X, Wang X, Teng Y, Chen D, Wang X, Ma B
Sci Total Environ
. 2024 Aug;
950:175145.
PMID: 39089382
Deep soil drying is a physical soil phenomenon that has become increasingly characteristic to artificial afforestation on China's Loess Plateau. Current research is largely short of conclusive reports on soil...
2.
Xie R, Zhen L, Wu X, Li J
Sci Total Environ
. 2023 Jan;
866:161438.
PMID: 36623659
Identifying the mixing processes of waters and currents in tidal reach is an important aspect of environmental management to protect freshwater resources and prevent water pollution. In this study, three...
3.
Cao H, Zong C, Dai W, Gao Q, Li D, Wu X, et al.
Front Cell Infect Microbiol
. 2021 Nov;
11:712028.
PMID: 34722329
Sepsis is a common and often treacherous medical emergency with a high mortality and long-term complications in survivors. Though antibiotic therapy can reduce death rate of sepsis significantly, it impairs...
4.
Nie P, Kalidindi T, Nagle V, Wu X, Li T, Liao G, et al.
Clin Cancer Res
. 2021 Sep;
27(22):6145-6155.
PMID: 34475100
Purpose: Abnormal Notch signaling promotes cancer cell growth and tumor progression in various cancers. Targeting γ-secretase, a pivotal regulator in the Notch pathway, has yielded numerous γ-secretase inhibitors (GSIs) for...
5.
Sinha A, Chang J, Xu P, Gindinova K, Cho Y, Sun W, et al.
ACS Med Chem Lett
. 2020 Oct;
11(10):1973-1979.
PMID: 33062181
Tafamidis, , a potent transthyretin kinetic stabilizer, weakly inhibits the γ-secretase enzyme . We have synthesized four amide derivatives of . These compounds reduce production of the Aβ peptide in...
6.
Hur J, Frost G, Wu X, Crump C, Pan S, Wong E, et al.
Nature
. 2020 Sep;
586(7831):735-740.
PMID: 32879487
Innate immunity is associated with Alzheimer's disease, but the influence of immune activation on the production of amyloid-β is unknown. Here we identify interferon-induced transmembrane protein 3 (IFITM3) as a...
7.
Luo W, Ip F, Fu G, Cheung K, Tian Y, Hu Y, et al.
ACS Chem Neurosci
. 2020 Aug;
11(18):2827-2835.
PMID: 32786303
Amyloid-beta peptides generated by β-secretase- and γ-secretase-mediated successive cleavage of amyloid precursor protein are believed to play a causative role in Alzheimer's disease. Thus, reducing amyloid-beta generation by modulating γ-secretase...
8.
Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, et al.
Chem Commun (Camb)
. 2020 Feb;
56(17):2578-2581.
PMID: 32016207
Combining NMR, mass spectrometry, AlphaLISA and cell assays, we discovered a compound C1 that binds C-terminal juxtamembrane lysines at the transmembrane domain of the amyloid precursor protein (APPTM) and inhibits...
9.
Crump C, Murrey H, Ballard T, Am Ende C, Wu X, Gertsik N, et al.
ACS Chem Neurosci
. 2016 Jun;
7(8):1166-73.
PMID: 27253220
γ-Secretase is a multiprotein complex that catalyzes intramembrane proteolysis associated with Alzheimer's disease and cancer. Here, we have developed potent sulfonamide clickable photoaffinity probes that target γ-secretase in vitro and...
10.
Zhang X, Sullivan E, Scimeca M, Wu X, Li Y, Sisodia S
J Biol Chem
. 2016 Feb;
291(13):6748-53.
PMID: 26887941
Understanding of the structure of the γ-secretase complex consisting of presenilin (PS), anterior pharynx-defective 1 (APH-1), nicastrin (NCT), and presenilin enhancer 2 (PEN-2) is of significant therapeutic interest for the...