Wouter Nijkamp
Overview
Explore the profile of Wouter Nijkamp including associated specialties, affiliations and a list of published articles.
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10
Citations
1165
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Recent Articles
1.
Berns K, Sonnenblick A, Gennissen A, Brohee S, Hijmans E, Evers B, et al.
Clin Cancer Res
. 2016 May;
22(21):5238-5248.
PMID: 27172896
Purpose: Despite the substantial progress in the development of targeted anticancer drugs, treatment failure due to primary or acquired resistance is still a major hurdle in the effective treatment of...
2.
Papadakis A, Sun C, Knijnenburg T, Xue Y, Grernrum W, Holzel M, et al.
Cell Res
. 2015 Feb;
25(4):445-58.
PMID: 25656847
Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as tumor suppressors in modulating oncogenic signaling pathways. We report here that...
3.
Bajpe P, Heynen G, Mittempergher L, Grernrum W, de Rink I, Nijkamp W, et al.
Mol Cell Biol
. 2013 Jun;
33(16):3343-53.
PMID: 23775127
Retinoids play key roles in development, differentiation, and homeostasis through regulation of specific target genes by the retinoic acid receptor/retinoid X receptor (RAR/RXR) nuclear receptor complex. Corepressors and coactivators contribute...
4.
Huang S, Holzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, et al.
Cell
. 2012 Nov;
151(5):937-50.
PMID: 23178117
Inhibitors of the ALK and EGF receptor tyrosine kinases provoke dramatic but short-lived responses in lung cancers harboring EML4-ALK translocations or activating mutations of EGFR, respectively. We used a large-scale...
5.
Westerman B, Braat A, Taub N, Potman M, Vissers J, Blom M, et al.
J Exp Med
. 2011 Dec;
208(13):2675-89.
PMID: 22143885
Despite intense investigation of intrinsic and extrinsic factors that regulate pluripotency, the process of initial fate commitment of embryonic stem (ES) cells is still poorly understood. We used a genome-wide...
6.
Holzel M, Huang S, Koster J, Ora I, Lakeman A, Caron H, et al.
Cell
. 2010 Jul;
142(2):218-29.
PMID: 20655465
Retinoic acid (RA) induces differentiation of neuroblastoma cells in vitro and is used with variable success to treat aggressive forms of this disease. This variability in clinical response to RA...
7.
Huang S, Laoukili J, Epping M, Koster J, Holzel M, Westerman B, et al.
Cancer Cell
. 2009 Apr;
15(4):328-40.
PMID: 19345331
Retinoids play key roles in differentiation, growth arrest, and apoptosis and are increasingly being used in the clinic for the treatment of a variety of cancers, including neuroblastoma. Here, using...
8.
Eichhorn P, Gili M, Scaltriti M, Serra V, Guzman M, Nijkamp W, et al.
Cancer Res
. 2008 Nov;
68(22):9221-30.
PMID: 19010894
Small molecule inhibitors of HER2 are clinically active in women with advanced HER2-positive breast cancer who have progressed on trastuzumab treatment. However, the effectiveness of this class of agents is...
9.
Kedde M, le Sage C, Duursma A, Zlotorynski E, van Leeuwen B, Nijkamp W, et al.
J Biol Chem
. 2006 Nov;
281(52):40503-14.
PMID: 17098743
The human telomerase RNA (hTR), together with the telomerase reverse transcriptase, hTERT, constitute the core components of telomerase that is essential for telomere maintenance. While hTR is ubiquitously expressed, hTERT...
10.
Berns K, Hijmans E, Mullenders J, Brummelkamp T, Velds A, Heimerikx M, et al.
Nature
. 2004 Mar;
428(6981):431-7.
PMID: 15042092
RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic screens in lower organisms and can greatly facilitate the identification of components of cellular signalling pathways....