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Wolfram Steinke

Explore the profile of Wolfram Steinke including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 390
Followers 0
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Recent Articles
1.
Janssen W, Schwarz T, Butehorn U, Steinke W, Sandmann S, Lang D, et al.
Xenobiotica . 2022 May; 52(5):453-462. PMID: 35616579
Vericiguat is a soluble guanylate cyclase stimulator. The pharmacokinetics, absorption, metabolism, and excretion properties of vericiguat in rats and dogs and the distribution in rats are reported. [C]-labelled vericiguat was...
2.
Zopf D, Fichtner I, Bhargava A, Steinke W, Thierauch K, Diefenbach K, et al.
Cancer Med . 2016 Oct; 5(11):3176-3185. PMID: 27734608
Regorafenib is an orally administered inhibitor of protein kinases involved in tumor angiogenesis, oncogenesis, and maintenance of the tumor microenvironment. Phase III studies showed that regorafenib has efficacy in patients...
3.
Kolkhof P, Delbeck M, Kretschmer A, Steinke W, Hartmann E, Barfacker L, et al.
J Cardiovasc Pharmacol . 2014 Mar; 64(1):69-78. PMID: 24621652
Pharmacological blockade of the mineralocorticoid receptor (MR) ameliorates end-organ damage in chronic heart failure. However, the clinical use of available steroidal MR antagonists is restricted because of concomitant hyperkalemia especially...
4.
Siemeister G, Lucking U, Wengner A, Lienau P, Steinke W, Schatz C, et al.
Mol Cancer Ther . 2012 Jul; 11(10):2265-73. PMID: 22821149
Deregulated activity of cyclin-dependent kinases (CDK) results in loss of cell-cycle checkpoint function and increased expression of antiapoptotic proteins, which has been directly linked to the molecular pathology of cancer....
5.
Haynes R, Fugmann B, Stetter J, Rieckmann K, Heilmann H, Chan H, et al.
Angew Chem Int Ed Engl . 2006 Jan; 45(13):2082-8. PMID: 16444785
No abstract available.
6.
Schwarz T, Beckermann B, Buehner K, Mauler F, Schuhmacher J, Seidel D, et al.
Biopharm Drug Dispos . 2005 Jun; 26(6):259-68. PMID: 15966026
Repinotan hydrochloride (repinotan) is a highly potent and selective 5-HT(1A) full receptor agonist. The ability of repinotan to cross the blood-brain barrier (BBB) and penetrate into rat brain tissue was...
7.
Stasch J, Schmidt P, Alonso-Alija C, Apeler H, Dembowsky K, Haerter M, et al.
Br J Pharmacol . 2002 Jun; 136(5):773-83. PMID: 12086987
1. Soluble guanylyl cyclase (sGC) is the only proven receptor for the ubiquitous biological messenger nitric oxide (NO) and is intimately involved in many signal transduction pathways, most notably in...