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Brian L Robinson

Explore the profile of Brian L Robinson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 162
Followers 0
Related Specialties
Chemistry
Biochemistry
Microbiology
Top 10 Co-Authors
Wallace Peters
Simon L Croft
Livia Vivas
Richard K Haynes
Ho-Wai Chan
Lindsay Stewart
Jorg Stetter
Burkhard Fugmann
Wing-Yan Ho
Dennis E Kyle
Published In
J Med Chem
Angew Chem Int Ed Engl
Chembiochem
J Parasitol
Int J Syst Evol Microbiol
Affiliations
Soon will be listed here.
Recent Articles
1.
Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo
Vivas L, Rattray L, Stewart L, Bongard E, Robinson B, Peters W, et al.
Acta Trop . 2008 Feb; 105(3):222-8. PMID: 18279817
Pyronaridine is a Mannich base anti-malarial with demonstrated efficacy against drug resistant Plasmodium falciparum, P. vivax, P. ovale and P. malariae. However, resistance to pyronaridine can develop quickly when it...
2.
Artemisone--a highly active antimalarial drug of the artemisinin class
Haynes R, Fugmann B, Stetter J, Rieckmann K, Heilmann H, Chan H, et al.
Angew Chem Int Ed Engl . 2006 Jan; 45(13):2082-8. PMID: 16444785
No abstract available.
3.
Phylogenetic analysis and description of Eperythrozoon coccoides, proposal to transfer to the genus Mycoplasma as Mycoplasma coccoides comb. nov. and Request for an Opinion
Neimark H, Peters W, Robinson B, Stewart L
Int J Syst Evol Microbiol . 2005 May; 55(Pt 3):1385-1391. PMID: 15879286
Eperythrozoon coccoides, an epierythrocytic organism that causes a mild haemolytic anaemia in laboratory and wild mice, currently is thought to be a rickettsia. To determine the relationship of this agent...
4.
Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate
Haynes R, Chan H, Ho W, Ko C, Gerena L, Kyle D, et al.
Chembiochem . 2005 Apr; 6(4):659-67. PMID: 15812783
An economical phase-transfer method is used to prepare 10-arylaminoartemisinins from DHA and arylamines, and artemether, arteether, and artelinate from the corresponding alcohols. In vivo sc screens against Plasmodium berghei and...
5.
Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity
Haynes R, Ho W, Chan H, Fugmann B, Stetter J, Croft S, et al.
Angew Chem Int Ed Engl . 2004 Sep; 43(11):1381-5. PMID: 15368412
No abstract available.
6.
Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line
Ferrer-Rodriguez I, Perez-Rosado J, Gervais G, Peters W, Robinson B, Serrano A
J Parasitol . 2004 Mar; 90(1):152-60. PMID: 15040683
The molecular mechanisms by which the malarial parasite has managed to develop resistance to many antimalarial drugs remain to be completely elucidated. Mutations in the pfmdr1 gene of Plasmodium falciparum,...
7.
Synthesis, stability, and antimalarial activity of new hydrolytically stable and water-soluble (+)-deoxoartelinic acid
Jung M, Lee K, Kendrick H, Robinson B, Croft S
J Med Chem . 2002 Oct; 45(22):4940-4. PMID: 12383020
(+)-Deoxoartelinic acid (13), a new hydrolytically stable, water-soluble, and potent non-acetal-type antimalarial drug candidate, was successfully prepared from artemisinic acid by using sulfur ylide and photooxygenative cyclization in seven steps....
8.
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates
Avery M, Alvim-Gaston M, Vroman J, Wu B, Ager A, Peters W, et al.
J Med Chem . 2002 Sep; 45(19):4321-35. PMID: 12213073
On the basis of earlier reported quantitative structure-activity relationship studies, a series of 9beta-16-(arylalkyl)-10-deoxoartemisinins were proposed for synthesis. Several of the new compounds 7 and 10-14 were synthesized employing the...