Wolfgang Schliebs
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Explore the profile of Wolfgang Schliebs including associated specialties, affiliations and a list of published articles.
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64
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1210
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Recent Articles
1.
Gaussmann S, Peschel R, Ott J, Zak K, Sastre J, Delhommel F, et al.
Nat Commun
. 2024 Apr;
15(1):3317.
PMID: 38632234
Import of proteins into peroxisomes depends on PEX5, PEX13 and PEX14. By combining biochemical methods and structural biology, we show that the C-terminal SH3 domain of PEX13 mediates intramolecular interactions...
2.
Mahadevan L, Arya H, Droste A, Schliebs W, Erdmann R, Kalel V
Front Cell Infect Microbiol
. 2024 Mar;
14:1274506.
PMID: 38510966
Trypanosomatid parasites are kinetoplastid protists that compartmentalize glycolytic enzymes in unique peroxisome-related organelles called glycosomes. The heterohexameric AAA-ATPase complex of PEX1-PEX6 is anchored to the peroxisomal membrane and functions in...
3.
Svensson C, Reglinski K, Schliebs W, Erdmann R, Eggeling C, Figge M
Sci Rep
. 2023 Nov;
13(1):19694.
PMID: 37951993
Diffusion and mobility are essential for cellular functions, as molecules are usually distributed throughout the cell and have to meet to interact and perform their function. This also involves the...
4.
Krishna C, Schmidt N, Tippler B, Schliebs W, Jung M, Winklhofer K, et al.
Front Cell Dev Biol
. 2023 Sep;
11:1213761.
PMID: 37664461
PEX19 binding sites are essential parts of the targeting signals of peroxisomal membrane proteins (mPTS). In this study, we characterized PEX19 binding sites of PEX11, the most abundant peroxisomal and...
5.
Marciniak M, Mroz P, Napolitano V, Kalel V, Fino R, Pykacz E, et al.
Eur J Med Chem
. 2023 Jul;
258:115587.
PMID: 37406382
Protein-protein interactions (PPIs) constitute an important but challenging class of molecular targets for small molecules. The PEX5-PEX14 PPI has been shown to play a critical role in glycosome biogenesis and...
6.
Peschel R, Schmidt N, Schliebs W, Erdmann R
Methods Mol Biol
. 2023 Mar;
2643:373-382.
PMID: 36952199
For a long time, the isolation of native protein complexes from human cells was accomplished by immunoprecipitation experiments. However, success depends on the quality of the antibodies and the method...
7.
Ott J, Sehr J, Schmidt N, Schliebs W, Erdmann R
Biol Chem
. 2022 Dec;
404(2-3):209-219.
PMID: 36534601
For the biogenesis and maintenance of peroxisomes several proteins, called peroxins, are essential. Malfunctions of these proteins lead to severe diseases summarized as peroxisome biogenesis disorders. The different genetic background...
8.
Gopalswamy M, Zheng C, Gaussmann S, Kooshapur H, Hambruch E, Schliebs W, et al.
Biol Chem
. 2022 Nov;
404(2-3):179-194.
PMID: 36437542
The cycling import receptor PEX5 and its membrane-located binding partner PEX14 are key constituents of the peroxisomal import machinery. Upon recognition of newly synthesized cargo proteins carrying a peroxisomal targeting...
9.
Yifrach E, Rudowitz M, Cruz-Zaragoza L, Tirosh A, Gazi Z, Peleg Y, et al.
Biol Chem
. 2022 Oct;
404(2-3):121-133.
PMID: 36279206
Accurate and regulated protein targeting is crucial for cellular function and proteostasis. In the yeast , peroxisomal matrix proteins, which harboring a Peroxisomal Targeting Signal 1 (PTS1), can utilize two...
10.
Blum D, Reuter M, Schliebs W, Tomaschewski J, Erdmann R, Wagner R
Biol Chem
. 2022 Oct;
404(2-3):157-167.
PMID: 36260915
The assembly of the peroxisomal translocon involves the transition of a soluble form of the peroxisomal targeting receptor PEX5 into a membrane-bound form, which becomes an integral membrane component of...