Ralf Erdmann
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Explore the profile of Ralf Erdmann including associated specialties, affiliations and a list of published articles.
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165
Citations
6300
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Recent Articles
1.
Carmichael R, Oeljeklaus S, Cruz-Zaragoza L, Kumar R, Bolton C, Islinger M, et al.
Histochem Cell Biol
. 2025 Jan;
163(1):24.
PMID: 39825042
No abstract available.
2.
Gaussmann S, Peschel R, Ott J, Zak K, Sastre J, Delhommel F, et al.
Nat Commun
. 2024 Apr;
15(1):3317.
PMID: 38632234
Import of proteins into peroxisomes depends on PEX5, PEX13 and PEX14. By combining biochemical methods and structural biology, we show that the C-terminal SH3 domain of PEX13 mediates intramolecular interactions...
3.
Platta H, Jeske J, Schmidt N, Erdmann R
Annu Rev Biochem
. 2024 Apr;
93(1):233-259.
PMID: 38621235
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal (PTS) receptors is an ATP-dependent...
4.
Mahadevan L, Arya H, Droste A, Schliebs W, Erdmann R, Kalel V
Front Cell Infect Microbiol
. 2024 Mar;
14:1274506.
PMID: 38510966
Trypanosomatid parasites are kinetoplastid protists that compartmentalize glycolytic enzymes in unique peroxisome-related organelles called glycosomes. The heterohexameric AAA-ATPase complex of PEX1-PEX6 is anchored to the peroxisomal membrane and functions in...
5.
Svensson C, Reglinski K, Schliebs W, Erdmann R, Eggeling C, Figge M
Sci Rep
. 2023 Nov;
13(1):19694.
PMID: 37951993
Diffusion and mobility are essential for cellular functions, as molecules are usually distributed throughout the cell and have to meet to interact and perform their function. This also involves the...
6.
Ruttermann M, Koci M, Lill P, Geladas E, Kaschani F, Klink B, et al.
Nat Commun
. 2023 Sep;
14(1):5942.
PMID: 37741838
The double-ring AAA+ ATPase Pex1/Pex6 is required for peroxisomal receptor recycling and is essential for peroxisome formation. Pex1/Pex6 mutations cause severe peroxisome associated developmental disorders. Despite its pathophysiological importance, mechanistic...
7.
Krishna C, Schmidt N, Tippler B, Schliebs W, Jung M, Winklhofer K, et al.
Front Cell Dev Biol
. 2023 Sep;
11:1213761.
PMID: 37664461
PEX19 binding sites are essential parts of the targeting signals of peroxisomal membrane proteins (mPTS). In this study, we characterized PEX19 binding sites of PEX11, the most abundant peroxisomal and...
8.
Rudowitz M, Erdmann R
J Cell Sci
. 2023 Aug;
136(15).
PMID: 37552037
Peroxisomes are involved in a multitude of metabolic and catabolic pathways, as well as the innate immune system. Their dysfunction is linked to severe peroxisome-specific diseases, as well as cancer...
9.
Marciniak M, Mroz P, Napolitano V, Kalel V, Fino R, Pykacz E, et al.
Eur J Med Chem
. 2023 Jul;
258:115587.
PMID: 37406382
Protein-protein interactions (PPIs) constitute an important but challenging class of molecular targets for small molecules. The PEX5-PEX14 PPI has been shown to play a critical role in glycosome biogenesis and...
10.
Chou S, Kalel V, Erdmann R
Methods Mol Biol
. 2023 Mar;
2643:445-453.
PMID: 36952205
Insect-transmitted trypanosomatid parasite infections cause life-threatening neglected tropical diseases (NTDs), including African sleeping sickness, Chagas disease and leishmaniasis. In these parasites, glycosomes are unique organelles that are essential for the...