William S Chen
Overview
Explore the profile of William S Chen including associated specialties, affiliations and a list of published articles.
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37
Citations
2369
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Recent Articles
1.
Chesner L, Polesso F, Graff J, Hawley J, Smith A, Lundberg A, et al.
Cancer Discov
. 2024 Dec;
15(3):481-494.
PMID: 39652470
Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This...
2.
Chen W, Abkar L, Mohseni M
J Biol Eng
. 2024 Nov;
18(1):63.
PMID: 39501290
Adenosine triphosphate (ATP) assays have a faster turnaround time and higher sensitivity than traditional cultivation methods for microbial monitoring. Challenges implementing ATP testing include incompatibility with chlorine quenching agents and...
3.
Sjostrom M, Zhao S, Levy S, Zhang M, Ning Y, Shrestha R, et al.
Cancer Res
. 2022 Oct;
82(21):3888-3902.
PMID: 36251389
Significance: In prostate cancer, 5-hydroxymethylcytosine delineates oncogene activation and stage-specific cell states and can be analyzed in liquid biopsies to detect cancer phenotypes. See related article by Wu and Attard,...
4.
5.
Rydzewski N, Peterson E, Lang J, Yu M, Chang S, Sjostrom M, et al.
NPJ Genom Med
. 2021 Sep;
6(1):76.
PMID: 34548481
We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a...
6.
Combes A, Courau T, Kuhn N, Hu K, Ray A, Chen W, et al.
Nature
. 2021 Aug;
596(7872):E8.
PMID: 34341540
No abstract available.
7.
Das R, Sjostrom M, Shrestha R, Yogodzinski C, Egusa E, Chesner L, et al.
Nat Commun
. 2021 Jul;
12(1):4601.
PMID: 34326322
Genomic sequencing of thousands of tumors has revealed many genes associated with specific types of cancer. Similarly, large scale CRISPR functional genomics efforts have mapped genes required for cancer cell...
8.
Combes A, Courau T, Kuhn N, Hu K, Ray A, Chen W, et al.
Nature
. 2021 Jan;
591(7848):124-130.
PMID: 33494096
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals, many others experience milder symptoms. Here, to gain a more comprehensive understanding...
9.
Combes A, Courau T, Kuhn N, Hu K, Ray A, Chen W, et al.
bioRxiv
. 2020 Nov;
PMID: 33140050
One Sentence Summary: In severe COVID-19 patients, the immune system fails to generate cells that define mild disease; antibodies in their serum actively prevents the successful production of those cells.
10.
Combes A, Courau T, Kuhn N, Hu K, Ray A, Chen W, et al.
Res Sq
. 2020 Nov;
PMID: 33140041
While SARS-CoV-2 infection has pleiotropic and systemic effects in some patients, many others experience milder symptoms. We sought a holistic understanding of the severe/mild distinction in COVID-19 pathology, and its...