William J Greenleaf
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Explore the profile of William J Greenleaf including associated specialties, affiliations and a list of published articles.
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168
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19220
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Recent Articles
11.
Shin J, Cuevas L, Roy R, Bonilla S, Al-Hashimi H, Greenleaf W, et al.
RNA
. 2024 Oct;
30(12):1646-1659.
PMID: 39362695
Folded RNAs contain tertiary contact motifs whose structures and energetics are conserved across different RNAs. The transferable properties of RNA motifs simplify the RNA folding problem, but measuring energetic and...
12.
Zhou B, Arthur J, Guo H, Kim T, Huang Y, Pattni R, et al.
Cell
. 2024 Oct;
187(23):6687-6706.e25.
PMID: 39353437
Complex structural variations (cxSVs) are often overlooked in genome analyses due to detection challenges. We developed ARC-SV, a probabilistic and machine-learning-based method that enables accurate detection and reconstruction of cxSVs...
13.
Jha A, Hristov B, Wang X, Wang S, Greenleaf W, Kundaje A, et al.
bioRxiv
. 2024 Sep;
PMID: 39345598
Three-dimensional nuclear DNA architecture comprises well-studied intra-chromosomal () folding and less characterized inter-chromosomal () interfaces. Current predictive models of 3D genome folding can effectively infer pairwise -chromatin interactions from the...
14.
Sundaram L, Kumar A, Zatzman M, Salcedo A, Ravindra N, Shams S, et al.
Science
. 2024 Sep;
385(6713):eadk9217.
PMID: 39236169
To identify cancer-associated gene regulatory changes, we generated single-cell chromatin accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas. Tumor chromatin accessibility is strongly influenced by...
15.
Tang Y, Xu H, Hughes N, Kim S, Ruiz P, Shuldiner E, et al.
bioRxiv
. 2024 Sep;
PMID: 39229041
Epigenetic dysregulation is widespread in cancer. However, the specific epigenetic regulators and the processes they control to drive cancer phenotypes are poorly understood. Here, we employed a novel, scalable and...
16.
Tan W, Seow W, Zhang A, Rhee S, Wong W, Greenleaf W, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(1):20-34.
PMID: 39196210
Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the recent remarkable progress in using single-cell technology to study transcriptomic...
17.
Kim Y, Calderon A, Favaro P, Glass D, Tsai A, Ho D, et al.
Nat Commun
. 2024 Jul;
15(1):5910.
PMID: 39003273
Lymphoid specification in human hematopoietic progenitors is not fully understood. To better associate lymphoid identity with protein-level cell features, we conduct a highly multiplexed single-cell proteomic screen on human bone...
18.
Marinov G, Ramalingam V, Greenleaf W, Kundaje A
bioRxiv
. 2024 Jun;
PMID: 38895386
In most eukaryotes, mitochondrial organelles contain their own genome, usually circular, which is the remnant of the genome of the ancestral bacterial endosymbiont that gave rise to modern mitochondria. Mitochondrial...
19.
Gamble N, Bradu A, Caldwell J, McKeever J, Bolonduro O, Ermis E, et al.
Nat Immunol
. 2024 May;
25(6):1123.
PMID: 38755325
No abstract available.
20.
Moses E, Atlan T, Sun X, Franek R, Siddiqui A, Marinov G, et al.
Nat Aging
. 2024 May;
4(6):791-813.
PMID: 38750187
Classical evolutionary theories propose tradeoffs among reproduction, damage repair and lifespan. However, the specific role of the germline in shaping vertebrate aging remains largely unknown. In this study, we used...