Ansuman T Satpathy
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Explore the profile of Ansuman T Satpathy including associated specialties, affiliations and a list of published articles.
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137
Citations
12234
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Recent Articles
1.
Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection
Roth T, Lu J, McClellan A, Kernick C, Takacsi-Nagy O, Satpathy A
Nat Biomed Eng
. 2025 Mar;
PMID: 40055580
Current methods for the precise integration of DNA sequences into the genome of human T cells predominantly target exonic regions, which limits the choice of integration site and requires complex...
2.
Raposo C, Yan P, Chen A, Majidi S, Hiam-Galvez K, Satpathy A
bioRxiv
. 2025 Feb;
PMID: 39990338
Immune checkpoint blockade can facilitate tumor clearance by T cells, resulting in long term patient survival. However, the capacity of exhausted CD8 T cells (Tex), present during chronic antigen exposure,...
3.
Cohen Shvefel S, Pai J, Cao Y, Pal L, Bartok O, Levy R, et al.
Cancer Discov
. 2025 Jan;
OF1-OF25.
PMID: 39873477
In this study, we find that Mif expression is associated with tumor growth and aggressiveness, specifically in tumors with low heterogeneity. These findings could facilitate the development of new strategies...
4.
Ngo W, Peukes J, Baldwin A, Xue Z, Hwang S, Stickels R, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2413519121.
PMID: 39793042
The widespread application of genome editing to treat and cure disease requires the delivery of genome editors into the nucleus of target cells. Enveloped delivery vehicles (EDVs) are engineered virally...
5.
Abay T, Stickels R, Takizawa M, Nalbant B, Hsieh Y, Hwang S, et al.
Nat Genet
. 2025 Jan;
57(2):451-460.
PMID: 39779958
Single-cell genomics technologies have accelerated our understanding of cell-state heterogeneity in diverse contexts. Although single-cell RNA sequencing identifies rare populations that express specific marker transcript combinations, traditional flow sorting requires...
6.
Cohen Shvefel S, Pai J, Cao Y, Pal L, Bartok O, Levy R, et al.
Cancer Discov
. 2024 Dec;
PMID: 39715301
Low intra-tumor heterogeneity (ITH) correlates with increased patient survival and immunotherapy response. However, even highly homogeneous tumors are variably aggressive, and the immunological factors impacting aggressiveness remain understudied. Here, we...
7.
Che Y, Lee J, Abou-Taleb F, Rieger K, Satpathy A, Chang A, et al.
bioRxiv
. 2024 Dec;
PMID: 39677742
Immune checkpoint inhibitors such as anti-PD-1 antibodies (aPD1) can be effective in treating advanced cancers. However, many patients do not respond and the mechanisms underlying these differences remain incompletely understood....
8.
Arce M, Umhoefer J, Arang N, Kasinathan S, Freimer J, Steinhart Z, et al.
Nature
. 2024 Dec;
637(8047):930-939.
PMID: 39663454
The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks. These dynamic regulatory circuits that respond to extracellular cues...
9.
Toh J, Reitsma A, Tajima T, Younes S, Ezeiruaku C, Jenkins K, et al.
Cell Rep Med
. 2024 Dec;
5(12):101851.
PMID: 39657667
The oncogenic Epstein-Barr virus (EBV) can drive tumorigenesis with disrupted host immunity, causing malignancies including post-transplant lymphoproliferative disorders (PTLDs). PTLD can also arise in the absence of EBV, but the...
10.
Sheth M, Qiu W, Ma X, Gschwind A, Jagoda E, Tan A, et al.
bioRxiv
. 2024 Nov;
PMID: 39605382
Mapping enhancers and their target genes in specific cell types is crucial for understanding gene regulation and human disease genetics. However, accurately predicting enhancer-gene regulatory interactions from single-cell datasets has...