Jason D Buenrostro
Overview
Explore the profile of Jason D Buenrostro including associated specialties, affiliations and a list of published articles.
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69
Citations
12528
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Recent Articles
1.
LaFave L, Kartha V, Ma S, Meli K, Del Priore I, Lareau C, et al.
Cancer Cell
. 2025 Mar;
PMID: 40054468
No abstract available.
2.
Nagaraja S, Ojeda-Miron L, Zhang R, Oreskovic E, Hu Y, Zeve D, et al.
bioRxiv
. 2025 Mar;
PMID: 40027722
Chronic inflammation is a well-established risk factor for cancer, but the underlying molecular mechanisms remain unclear. Using a mouse model of colitis, we demonstrate that colonic stem cells retain an...
3.
Chandra N, Hu Y, Buenrostro J, Mostafavi S, Sasse A
bioRxiv
. 2025 Feb;
PMID: 39975126
Chromatin accessibility can be measured genome-wide with ATAC-seq, enabling the discovery of regulatory regions that control gene expression and determine cell type. Deep genomic sequence-to-function (S2F) models link underlying genomic...
4.
Moore M, Wekhande S, Issner R, Collins A, Cruz A, Liu Y, et al.
Nat Commun
. 2025 Feb;
16(1):1357.
PMID: 39905017
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity...
5.
Hu Y, Horlbeck M, Zhang R, Ma S, Shrestha R, Kartha V, et al.
Nature
. 2025 Jan;
638(8051):779-786.
PMID: 39843737
Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure and function, reflecting changes in the composition of diverse effector proteins over time. However, methods for measuring the...
6.
Labade A, Chiang Z, Comenho C, Reginato P, Payne A, Earl A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386718
Microscopy and genomics are both used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. While emerging multiplexed imaging methods...
7.
Hingerl J, Martens L, Karollus A, Manz T, Buenrostro J, Theis F, et al.
bioRxiv
. 2024 Sep;
PMID: 39345504
Understanding how regulatory DNA elements shape gene expression across individual cells is a fundamental challenge in genomics. Joint RNA-seq and epigenomic profiling provides opportunities to build unifying models of gene...
8.
Thakore P, Schnell A, Huang L, Zhao M, Hou Y, Christian E, et al.
Nat Immunol
. 2024 Jul;
25(8):1395-1410.
PMID: 39009838
Interleukin-17 (IL-17)-producing helper T (T17) cells are heterogenous and consist of nonpathogenic T17 (npT17) cells that contribute to tissue homeostasis and pathogenic T17 (pT17) cells that mediate tissue inflammation. Here,...
9.
Schiroli G, Kartha V, Duarte F, Kristiansen T, Mayerhofer C, Shrestha R, et al.
Nat Commun
. 2024 May;
15(1):4325.
PMID: 38773071
Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigate how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using...
10.
Joung J, Ma S, Tay T, Geiger-Schuller K, Kirchgatterer P, Verdine V, et al.
Cell
. 2024 May;
187(12):3161.
PMID: 38697106
No abstract available.