Maxwell R Mumbach
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Explore the profile of Maxwell R Mumbach including associated specialties, affiliations and a list of published articles.
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35
Citations
6765
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Recent Articles
1.
Drake K, Talantov D, Tong G, Lin J, Verheijden S, Katz S, et al.
Clin Immunol
. 2023 Oct;
256:109808.
PMID: 37852344
We sought to better understand the immune response during the immediate post-diagnosis phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by identifying molecular associations with longitudinal disease outcomes. Multi-omic...
2.
Moonen J, Chappell J, Shi M, Shinohara T, Li D, Mumbach M, et al.
Nat Commun
. 2022 Aug;
13(1):4941.
PMID: 35999210
Physiologic laminar shear stress (LSS) induces an endothelial gene expression profile that is vasculo-protective. In this report, we delineate how LSS mediates changes in the epigenetic landscape to promote this...
3.
Maciag K, Raychowdhury R, Smith K, Schneider A, Coers J, Mumbach M, et al.
J Leukoc Biol
. 2021 Nov;
112(2):257-271.
PMID: 34826345
Macrophages use an array of innate immune sensors to detect intracellular pathogens and to tailor effective antimicrobial responses. In addition, extrinsic activation with the cytokine IFN-γ is often required as...
4.
Gennert D, Lynn R, Granja J, Weber E, Mumbach M, Zhao Y, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34285077
Dysfunction in T cells limits the efficacy of cancer immunotherapy. We profiled the epigenome, transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting HA-28z chimeric antigen receptor (CAR) T cells and control...
5.
Flynn R, Belk J, Qi Y, Yasumoto Y, Wei J, Alfajaro M, et al.
Cell
. 2021 Mar;
184(9):2394-2411.e16.
PMID: 33743211
SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host proteins that bind the SARS-CoV-2...
6.
Corces M, Shcherbina A, Kundu S, Gloudemans M, Fresard L, Granja J, et al.
Nat Genet
. 2020 Oct;
52(11):1158-1168.
PMID: 33106633
Genome-wide association studies of neurological diseases have identified thousands of variants associated with disease phenotypes. However, most of these variants do not alter coding sequences, making it difficult to assign...
7.
Flynn R, Belk J, Qi Y, Yasumoto Y, Schmitz C, Mumbach M, et al.
bioRxiv
. 2020 Oct;
PMID: 33052334
Highlights: · ChIRP-MS of SARS-CoV-2 RNA identifies a comprehensive viral RNA-host protein interaction network during infection across two species· Comparison to RNA-protein interaction networks with Zika virus, dengue virus, and...
8.
Wilson K, Ameen M, Guo H, Abilez O, Tian L, Mumbach M, et al.
Dev Cell
. 2020 Aug;
54(6):694-709.e9.
PMID: 32763147
Transposable elements (TEs) comprise nearly half of the human genome and are often transcribed or exhibit cis-regulatory properties with unknown function in specific processes such as heart development. In the...
9.
Nasrallah R, Imianowski C, Bossini-Castillo L, Grant F, Dogan M, Placek L, et al.
Nature
. 2020 Jun;
583(7816):447-452.
PMID: 32499651
Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers. The functions of a large majority of disease-associated enhancers are unknown, in...
10.
Lopez-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy A, Granja J, et al.
Nat Commun
. 2019 Nov;
10(1):4955.
PMID: 31672989
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous...