William J Greenleaf
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Explore the profile of William J Greenleaf including associated specialties, affiliations and a list of published articles.
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168
Citations
19220
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Recent Articles
1.
Schaepe J, Fries T, Doughty B, Crocker O, Hinks M, Marklund E, et al.
bioRxiv
. 2025 Feb;
PMID: 39975040
The molecular details governing transcription factor (TF) binding and the formation of accessible chromatin are not yet quantitatively understood - including how sequence context modulates affinity, how TFs search DNA,...
2.
Adli M, Przybyla L, Burdett T, Burridge P, Cacheiro P, Chang H, et al.
Nature
. 2025 Feb;
638(8050):351-359.
PMID: 39939790
Recent advances in functional genomics and human cellular models have substantially enhanced our understanding of the structure and regulation of the human genome. However, our grasp of the molecular functions...
3.
Zhu Y, Lee H, White S, Weimer A, Monte E, Horning A, et al.
Nat Cancer
. 2025 Jan;
6(2):404.
PMID: 39865177
No abstract available.
4.
Guha T, Esplin E, Horning A, Chiu R, Paul K, Weimer A, et al.
bioRxiv
. 2024 Nov;
PMID: 39605357
Colorectal cancer (CRC) is the third leading cause of cancer mortality in the United States. Familial adenomatous polyposis (FAP) is a hereditary syndrome that raises the risk of developing CRC,...
5.
Kim S, Marinov G, Greenleaf W
Genome Res
. 2024 Nov;
35(1):124-134.
PMID: 39572230
Gene regulation in most eukaryotes involves two fundamental processes: alterations in genome packaging by nucleosomes, with active -regulatory elements (CREs) generally characterized by open-chromatin configuration, and transcriptional activation. Mapping these...
6.
Marinov G, Doughty B, Kundaje A, Greenleaf W
Genome Res
. 2024 Nov;
35(1):109-123.
PMID: 39572228
Histone proteins have traditionally been thought to be restricted to eukaryotes and most archaea, with eukaryotic nucleosomal histones deriving from their archaeal ancestors. In contrast, bacteria lack histones as a...
7.
Doughty B, Hinks M, Schaepe J, Marinov G, Thurm A, Rios-Martinez C, et al.
Nature
. 2024 Nov;
636(8043):745-754.
PMID: 39567683
The binding of multiple transcription factors (TFs) to genomic enhancers drives gene expression in mammalian cells. However, the molecular details that link enhancer sequence to TF binding, promoter state and...
8.
Tang J, Weiser N, Wang G, Chowdhry S, Curtis E, Zhao Y, et al.
Nature
. 2024 Nov;
635(8037):210-218.
PMID: 39506153
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival. At...
9.
Esplin E, Hanson C, Wu S, Horning A, Barapour N, Nevins S, et al.
Nat Cancer
. 2024 Oct;
5(11):1737-1753.
PMID: 39478120
Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and is an ideal model to study transitions of early precancer states to colorectal...
10.
Zhu Y, Lee H, White S, Weimer A, Monte E, Horning A, et al.
Nat Cancer
. 2024 Oct;
5(11):1697-1712.
PMID: 39478119
Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. We traced the evolution and malignant transformation of colorectal cancer (CRC) by generating high-resolution...