Wenke Jonas
Overview
Explore the profile of Wenke Jonas including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
617
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Recent Articles
1.
Sehgal R, Jahnert M, Lazaratos M, Speckmann T, Schumacher F, Kleuser B, et al.
J Lipid Res
. 2025 Mar;
:100767.
PMID: 40044043
Present study explores the role of liver lipidome in driving T2D-associated metabolic changes. Elevated liver triacylglycerols, reduced PUFAs, and 86 differentially abundant lipid species were identified in diabetes-prone mice. Of...
2.
Chopra S, Kadiri O, Ulke J, Hauffe R, Jonas W, Cheshmeh S, et al.
Cell Rep
. 2024 Nov;
43(12):114984.
PMID: 39589923
A healthy metabolism relies on precise regulation of anabolic and catabolic pathways. While insulin deficiency impairs anabolism, insulin resistance in obesity causes metabolic dysfunction, especially via altered brain insulin receptor...
3.
Gaugel J, Haacke N, Sehgal R, Jahnert M, Jonas W, Hoffmann A, et al.
Mol Metab
. 2024 Aug;
88:102014.
PMID: 39182843
Objective: Picalm (phosphatidylinositol-binding clathrin assembly protein), a ubiquitously expressed clathrin-adapter protein, is a well-known susceptibility gene for Alzheimer's disease, but its role in white adipose tissue (WAT) function has not...
4.
Lenihan-Geels G, Garcia Carrizo F, Leer M, Gohlke S, Oster M, Pohle-Kronawitter S, et al.
J Cachexia Sarcopenia Muscle
. 2024 Jul;
15(5):1772-1784.
PMID: 39010299
Background: The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility...
5.
Igual Gil C, Coull B, Jonas W, Lippert R, Klaus S, Ost M
Life Sci Alliance
. 2022 Oct;
5(11).
PMID: 36271504
Growth differentiation factor 15 (GDF15) is a mitochondrial stress-induced cytokine that modulates energy balance in an endocrine manner. However, the importance of its brainstem-restricted receptor GDNF family receptor alpha-like (GFRAL)...
6.
Jonas W, Schwerbel K, Zellner L, Jahnert M, Gottmann P, Schurmann A
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233162
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Various mechanisms such as an increased uptake in fatty acids or de novo synthesis contribute to...
7.
Hauffe R, Rath M, Agyapong W, Jonas W, Vogel H, Schulz T, et al.
Antioxidants (Basel)
. 2022 May;
11(5).
PMID: 35624726
The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial...
8.
Jonas W, Kluth O, Helms A, Voss S, Jahnert M, Gottmann P, et al.
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328627
Current attempts to prevent and manage type 2 diabetes have been moderately effective, and a better understanding of the molecular roots of this complex disease is important to develop more...
9.
Hauffe R, Rath M, Schell M, Ritter K, Kappert K, Deubel S, et al.
Mol Metab
. 2021 Jun;
53:101276.
PMID: 34153520
Objective: Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60. The...
10.
Jonas W, Schurmann A
Mol Metab
. 2020 Nov;
50:101111.
PMID: 33160101
Background: Hepatic steatosis is a common chronic liver disease that can progress into more severe stages of NAFLD or promote the development of life-threatening secondary diseases for some of those...