Wen-Shu Wu
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Explore the profile of Wen-Shu Wu including associated specialties, affiliations and a list of published articles.
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36
Citations
1027
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Recent Articles
1.
Wang P, Kang Q, Wu W, Rui L
Cell Rep
. 2024 Mar;
43(3):113875.
PMID: 38451818
Liver injury stimulates hepatocyte replication and hepatic stellate cell (HSC) activation, thereby driving liver regeneration. Aberrant HSC activation induces liver fibrosis. However, mechanisms underlying liver regeneration and fibrosis remain poorly...
2.
Wu W, Yan X, Chen S, Du Y, Hu J, Song Y, et al.
Adv Mater
. 2024 Mar;
36(26):e2309770.
PMID: 38447017
Percutaneous thermotherapy, a minimally invasive operational procedure, is employed in the ablation of deep tumor lesions by means of target-delivering heat. Conventional thermal ablation methods, such as radiofrequency or microwave...
3.
Ge Y, Hong M, Zhang Y, Wang J, Li L, Zhu H, et al.
Haematologica
. 2023 Aug;
109(2):411-421.
PMID: 37584287
Leukemia stem cells (LSC) represent a crucial and rare subset of cells present in acute myeloid leukemia (AML); they play a pivotal role in the initiation, maintenance, and relapse of...
4.
LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice
Kim M, Li Y, Zheng Q, Jiang L, Myers Jr M, Wu W, et al.
J Clin Invest
. 2022 Dec;
133(4).
PMID: 36512408
Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to cause obesity. The transcription factor Slug - also known...
5.
Liu Y, Lin H, Jiang L, Shang Q, Yin L, Lin J, et al.
J Clin Invest
. 2020 May;
130(6):2992-3004.
PMID: 32365055
De novo lipogenesis is tightly regulated by insulin and nutritional signals to maintain metabolic homeostasis. Excessive lipogenesis induces lipotoxicity, leading to nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes....
6.
Chen Z, Li L, Xu S, Liu Z, Zhou C, Li Z, et al.
Cell Death Dis
. 2020 Mar;
11(3):180.
PMID: 32152291
Forkhead box M1 (FoxM1) transcriptional factor has a principal role in regulating cell proliferation, self-renewal, and tumorigenesis. However, whether FoxM1 regulates endogenous muscle development and regeneration remains unclear. Here we...
7.
Zhang Z, Li L, Wu C, Yin G, Zhu P, Zhou Y, et al.
Leukemia
. 2019 Sep;
34(2):380-390.
PMID: 31492896
Leukemia stem cells (LSCs) are the rare populations of acute myeloid leukemia (AML) cells that are able to initiate, maintain, and propagate AML. Targeting LSCs is a promising approach for...
8.
Zhu P, Zhang C, Gao Y, Wu F, Zhou Y, Wu W
Nat Commun
. 2019 Jun;
10(1):2568.
PMID: 31189923
Activation of the p16-associated senescence pathway during aging breaks muscle homeostasis and causes degenerative muscle disease by irreversibly dampening satellite cell (SC) self-renewal capacity. Here, we report that the zinc-finger...
9.
Zhang Z, Wu W
Methods Mol Biol
. 2018 Feb;
1733:255-263.
PMID: 29435939
MicroRNAs are small 18-24 nt single-stranded noncoding RNA molecules involved in many biological processes, including stemness maintenance and cellular reprogramming. Current methods used in loss-of-function studies of microRNAs have several...
10.
Zhu P, Wu F, Mosenson J, Zhang H, He T, Wu W
Mol Ther Nucleic Acids
. 2017 Jun;
7:31-41.
PMID: 28624206
Muscle stem cells (MuSCs) hold great therapeutic potential for muscle genetic disorders, such as Duchenne muscular dystrophy (DMD). The CRISP/Cas9-based genome editing is a promising technology for correcting genetic alterations...