Wayne Stallaert
Overview
Explore the profile of Wayne Stallaert including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
305
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Recent Articles
1.
Jiang Q, Jiang Q, Ertel M, Arrigo A, Sannino S, Goeckeler-Fried J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990343
Cytotoxic chemotherapy remains the primary treatment for ovarian cancer (OvCa). Development of chemoresistance typically results in patient death within two years. As such, understanding chemoresistance is critical. One underexplored mechanism...
2.
Wen O, Wolff S, Stallaert W, Li D, Purvis J, Zikry T
Pac Symp Biocomput
. 2024 Dec;
30:473-487.
PMID: 39670390
CDK4/6 inhibitors such as palbociclib block cell cycle progression and improve outcomes for many ER+/HER2- breast cancer patients. Unfortunately, many patients are initially resistant to the drug or develop resistance...
3.
Shah O, Nasrazadani A, Foldi J, Atkinson J, Kleer C, McAuliffe P, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2322068121.
PMID: 39042692
Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadherin positive ductal and E-cadherin negative lobular morphologies within the same tumor, posing...
4.
Shah O, Nasrazadani A, Foldi J, Atkinson J, Kleer C, McAuliffe P, et al.
bioRxiv
. 2024 Jun;
PMID: 38915645
Significance: MDLC displays both ductal and lobular tumor regions. Our multi-omic profiling approach revealed that these morphologically distinct tumor regions harbor distinct intrinsic subtypes and oncogenic features that may cause...
5.
Ranek J, Stallaert W, Milner J, Redick M, Wolff S, Beltran A, et al.
Nat Commun
. 2024 Mar;
15(1):2765.
PMID: 38553455
Single-cell technologies can measure the expression of thousands of molecular features in individual cells undergoing dynamic biological processes. While examining cells along a computationally-ordered pseudotime trajectory can reveal how changes...
6.
Kedziora K, Stallaert W
Methods Mol Biol
. 2024 Feb;
2740:243-262.
PMID: 38393480
The development of technologies that allow measurement of the cell cycle at the single-cell level has revealed novel insights into the mechanisms that regulate cell cycle commitment and progression through...
7.
Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu N, et al.
bioRxiv
. 2024 Feb;
PMID: 38370789
Homologous recombination (HR) deficiency enhances sensitivity to DNA damaging agents commonly used to treat cancer. In HR-proficient cancers, metabolic mechanisms driving response or resistance to DNA damaging agents remain unclear....
8.
Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2- breast tumor cells
Zikry T, Wolff S, Ranek J, Davis H, Naugle A, Luthra N, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(7):e2309261121.
PMID: 38324568
The CDK4/6 inhibitor palbociclib blocks cell cycle progression in Estrogen receptor-positive, human epidermal growth factor 2 receptor-negative (ER+/HER2-) breast tumor cells. Despite the drug's success in improving patient outcomes, a...
9.
Ranek J, Stallaert W, Milner J, Stanley N, Purvis J
bioRxiv
. 2023 May;
PMID: 37214963
Single-cell technologies can readily measure the expression of thousands of molecular features from individual cells undergoing dynamic biological processes, such as cellular differentiation, immune response, and disease progression. While examining...
10.
Stallaert W, Taylor S, Kedziora K, Taylor C, Sobon H, Young C, et al.
Mol Syst Biol
. 2022 Sep;
18(9):e11087.
PMID: 36161508
The cellular decision governing the transition between proliferative and arrested states is crucial to the development and function of every tissue. While the molecular mechanisms that regulate the proliferative cell...