Wayne Mitchell
Overview
Explore the profile of Wayne Mitchell including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
1072
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Recent Articles
1.
Mitchell W, Pharaoh G, Tyshkovskiy A, Campbell M, Marcinek D, Gladyshev V
Aging Cell
. 2025 Mar;
:e70026.
PMID: 40080911
Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondria-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated...
2.
Gladyshev V, Anderson B, Barlit H, Barre B, Beck S, Behrouz B, et al.
PNAS Nexus
. 2024 Dec;
3(12):pgae499.
PMID: 39660064
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the...
3.
Mitchell W, Pharaoh G, Tyshkovskiy A, Campbell M, Marcinek D, Gladyshev V
bioRxiv
. 2024 Nov;
PMID: 39554099
Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondrial-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated...
4.
Ebert A, Harper S, Vestergaard M, Mitchell W, Jess T, Elmahdi R
Nat Commun
. 2024 Sep;
15(1):8383.
PMID: 39333475
Infectious mononucleosis (IM) is suspected to be associated with inflammatory bowel disease (IBD) development. Using a Danish nationwide cohort of people developing severe IM and their age-, sex-, and socioeconomic...
5.
Rua A, Mitchell W, Claypool S, Alder N, Alexandrescu A
J Biol Chem
. 2024 Sep;
300(10):107746.
PMID: 39236875
Mitochondria are central to cellular metabolism; hence, their dysfunction contributes to a wide array of human diseases. Cardiolipin, the signature phospholipid of the mitochondrion, affects proper cristae morphology, bioenergetic functions,...
6.
Rua A, Mitchell W, Claypool S, Alder N, Alexandrescu A
bioRxiv
. 2024 Jul;
PMID: 38948727
Mitochondria are central to cellular metabolism; hence, their dysfunction contributes to a wide array of human diseases including cancer, cardiopathy, neurodegeneration, and heritable pathologies such as Barth syndrome. Cardiolipin, the...
7.
Rothi M, Haddad J, Sarkar G, Mitchell W, Ying K, Pohl N, et al.
Res Sq
. 2024 Jul;
PMID: 38946979
Ribosome heterogeneity has emerged as an important regulatory control feature for determining which proteins are synthesized, however, the influence of age on ribosome heterogeneity is not fully understood. Whether mRNA...
8.
Rothi M, Sarkar G, Haddad J, Mitchell W, Ying K, Pohl N, et al.
bioRxiv
. 2024 May;
PMID: 38798397
Ribosome heterogeneity has emerged as an important regulatory control feature for determining which proteins are synthesized, however, the influence of age on ribosome heterogeneity is not fully understood. Whether mRNA...
9.
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
Mitchell W, Goeminne L, Tyshkovskiy A, Zhang S, Chen J, Paulo J, et al.
Elife
. 2024 Mar;
12.
PMID: 38517750
Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery...
10.
Reed A, Mitchell W, Alexandrescu A, Alder N
Front Physiol
. 2023 Nov;
14:1263420.
PMID: 38028797
Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial targeting sequences (MTSs, or "presequences") that are recognized by the import machinery and subsequently cleaved to yield the mature...