Nathan N Alder
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Explore the profile of Nathan N Alder including associated specialties, affiliations and a list of published articles.
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40
Citations
990
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Recent Articles
1.
Zhao T, Li A, Reese B, Cong Q, Corwin E, Taylor S, et al.
Interdiscip Nurs Res
. 2024 Nov;
3(3):149-156.
PMID: 39554223
Objectives: Mitochondrial DNA copy number (mtDNAcn) is associated with mitochondrial function, with abnormal copy numbers having been linked to various disease states. Our study aims to understand the association between...
2.
Rua A, Mitchell W, Claypool S, Alder N, Alexandrescu A
J Biol Chem
. 2024 Sep;
300(10):107746.
PMID: 39236875
Mitochondria are central to cellular metabolism; hence, their dysfunction contributes to a wide array of human diseases. Cardiolipin, the signature phospholipid of the mitochondrion, affects proper cristae morphology, bioenergetic functions,...
3.
Rua A, Mitchell W, Claypool S, Alder N, Alexandrescu A
bioRxiv
. 2024 Jul;
PMID: 38948727
Mitochondria are central to cellular metabolism; hence, their dysfunction contributes to a wide array of human diseases including cancer, cardiopathy, neurodegeneration, and heritable pathologies such as Barth syndrome. Cardiolipin, the...
4.
Senoo N, Chinthapalli D, Baile M, Golla V, Saha B, Oluwole A, et al.
EMBO J
. 2024 Jun;
43(14):2979-3008.
PMID: 38839991
Lipid-protein interactions play a multitude of essential roles in membrane homeostasis. Mitochondrial membranes have a unique lipid-protein environment that ensures bioenergetic efficiency. Cardiolipin (CL), the signature mitochondrial lipid, plays multiple...
5.
Zhao T, Chang X, Biswas S, Balsbaugh J, Liddle J, Chen M, et al.
Dev Neurosci
. 2024 Jan;
46(5):341-352.
PMID: 38286121
Introduction: Preterm infants experience tremendous early life pain/stress during their neonatal intensive care unit (NICU) hospitalization, which impacts their neurodevelopmental outcomes. Mitochondrial function/dysfunction may interface between perinatal stress events and...
6.
Kunze M, Alder N, Hwang I, Roussel G, Karamyshev A
Front Physiol
. 2023 Dec;
14:1338852.
PMID: 38143916
No abstract available.
7.
Reed A, Mitchell W, Alexandrescu A, Alder N
Front Physiol
. 2023 Nov;
14:1263420.
PMID: 38028797
Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial targeting sequences (MTSs, or "presequences") that are recognized by the import machinery and subsequently cleaved to yield the mature...
8.
Tamucci J, Alder N, May E
Mol Pharm
. 2023 Oct;
20(12):6114-6129.
PMID: 37904323
Mitochondrial dysfunction is implicated in nine of the ten leading causes of death in the US, yet there are no FDA-approved therapeutics to treat it. Synthetic mitochondria-targeted peptides (MTPs), including...
9.
Ng E, Reed A, OConnell C, Alder N
J Vis Exp
. 2023 Jul;
(196).
PMID: 37458423
Mitochondria play many essential roles in the cell, including energy production, regulation of Ca homeostasis, lipid biosynthesis, and production of reactive oxygen species (ROS). These mitochondria-mediated processes take on specialized...
10.
Senoo N, Chinthapalli D, Baile M, Golla V, Saha B, Ogunbona O, et al.
bioRxiv
. 2023 May;
PMID: 37205478
The mitochondrial phospholipid cardiolipin (CL) promotes bioenergetics via oxidative phosphorylation (OXPHOS). Three tightly bound CLs are evolutionarily conserved in the ADP/ATP carrier (AAC in yeast; adenine nucleotide translocator, ANT in...