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Vadim N Gladyshev

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Articles 436
Citations 18610
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Recent Articles
1.
Mitchell W, Pharaoh G, Tyshkovskiy A, Campbell M, Marcinek D, Gladyshev V
Aging Cell . 2025 Mar; :e70026. PMID: 40080911
Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondria-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated...
2.
Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, et al.
Nat Aging . 2025 Mar; PMID: 40055478
Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be...
3.
Sun F, Desevin K, Fu Y, Parameswaran S, Mayall J, Rinaldi V, et al.
G3 (Bethesda) . 2025 Mar; PMID: 40036847
During mammalian reproduction, sperm are delivered to the female reproductive tract bathed in a complex medium known as seminal fluid, which plays key roles in signaling to the female reproductive...
4.
Ferrucci L, Barzilai N, Belsky D, Gladyshev V
Nat Med . 2025 Feb; PMID: 40011691
No abstract available.
5.
Moqri M, Poganik J, Horvath S, Gladyshev V
Nat Aging . 2025 Feb; PMID: 39994479
No abstract available.
6.
Rogina B, Anderson R, LeBrasseur N, Curan S, Yousefzadeh M, Ghosh B, et al.
J Gerontol A Biol Sci Med Sci . 2025 Feb; PMID: 39932386
The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic...
7.
Tanaka T, Sierra F, Gladyshev V, Wyss-Coray T, Cuervo A, Perez V, et al.
Nat Aging . 2025 Feb; 5(2):188-192. PMID: 39915640
No abstract available.
8.
Cohen A, Beard J, Ferrucci L, Fulop T, Gladyshev V, Moqri M, et al.
Nat Aging . 2025 Jan; 5(1):4-8. PMID: 39753893
No abstract available.
9.
Gladyshev V, Anderson B, Barlit H, Barre B, Beck S, Behrouz B, et al.
PNAS Nexus . 2024 Dec; 3(12):pgae499. PMID: 39660064
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the...
10.
Shim H, Lee H, Cho H, Jo Y, Tarrago L, Kim H, et al.
Antioxidants (Basel) . 2024 Nov; 13(11). PMID: 39594490
MsrB1 is a thiol-dependent enzyme that reduces protein methionine--sulfoxide and regulates inflammatory response in macrophages. Therefore, MsrB1 could be a promising therapeutic target for the control of inflammation. To identify...