Walt F Lima
Overview
Explore the profile of Walt F Lima including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
30
Citations
1317
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Hu J, Liu J, Narayanannair K, Lackey J, Kuchimanchi S, Rajeev K, et al.
Biochemistry
. 2014 Jul;
53(28):4510-8.
PMID: 24981774
Dentatorubral-pallidoluysian atrophy (DRPLA) is a progressive neurodegenerative disorder that currently has no curative treatments. DRPLA is caused by an expansion of a CAG trinucleotide repeat region within the protein-encoding sequence...
12.
Hu J, Liu J, Yu D, Aiba Y, Lee S, Pendergraff H, et al.
Nucleic Acid Ther
. 2014 Apr;
24(3):199-209.
PMID: 24694346
Mutant huntingtin (HTT) protein is the cause of Huntington's disease (HD), an incurable neurological disorder. Almost all patients are heterozygous for mutant HTT and approaches that reduce levels of mutant...
13.
Wu H, Sun H, Liang X, Lima W, Crooke S
PLoS One
. 2013 Aug;
8(8):e71006.
PMID: 23990920
Mammalian RNase H1 has been implicated in mitochondrial DNA replication and RNA processing and is required for embryonic development. We identified the mitochondrial protein P32 that binds specifically to human...
14.
Liu J, Yu D, Aiba Y, Pendergraff H, Swayze E, Lima W, et al.
Nucleic Acids Res
. 2013 Aug;
41(20):9570-83.
PMID: 23935115
Single-stranded silencing RNAs (ss-siRNAs) provide an alternative approach to gene silencing. ss-siRNAs combine the simplicity and favorable biodistribution of antisense oligonucleotides with robust silencing through RNA interference (RNAi). Previous studies...
15.
Prakash T, Lima W, Murray H, Elbashir S, Cantley W, Foster D, et al.
ACS Chem Biol
. 2013 Apr;
8(7):1402-6.
PMID: 23614580
We evaluated the abilities of an antisense oligonucleotide (ASO), a small interfering RNA (siRNA), and a single-stranded siRNA (ss-siRNA) to inhibit expression from the PTEN gene in mice when formulated...
16.
Yu D, Pendergraff H, Liu J, Kordasiewicz H, Cleveland D, Swayze E, et al.
Cell
. 2012 Sep;
150(5):895-908.
PMID: 22939619
Mutant huntingtin (HTT) protein causes Huntington disease (HD), an incurable neurological disorder. Silencing mutant HTT using nucleic acids would eliminate the root cause of HD. Developing nucleic acid drugs is...
17.
Lima W, Prakash T, Murray H, Kinberger G, Li W, Chappell A, et al.
Cell
. 2012 Sep;
150(5):883-94.
PMID: 22939618
The therapeutic utility of siRNAs is limited by the requirement for complex formulations to deliver them to tissues. If potent single-stranded RNAs could be identified, they would provide a simpler...
18.
Vickers T, Lima W, Wu H, Nichols J, Linsley P, Crooke S
Nucleic Acids Res
. 2009 Sep;
37(20):6927-41.
PMID: 19767612
It is known that siRNAs are capable of reducing expression of non-target genes due to the interaction of the siRNA guide strand with a partially complementary site on the 'off-target'...
19.
Lima W, Wu H, Nichols J, Sun H, Murray H, Crooke S
J Biol Chem
. 2009 Jul;
284(38):26017-28.
PMID: 19625255
The endonuclease Argonaute2 (Ago2) mediates the degradation of the target mRNA within the RNA-induced silencing complex. We determined the binding and cleavage properties of recombinant human Ago2. Human Ago2 was...
20.
Lima W, Murray H, Nichols J, Wu H, Sun H, Prakash T, et al.
J Biol Chem
. 2008 Nov;
284(4):2535-48.
PMID: 19017633
Human Dicer is an integral component of the RNA interference pathway. Dicer processes premicro-RNA and double-strand RNA to, respectively, mature micro-RNA and short interfering RNA (siRNA) and transfers the processed...