W Michael Seganish
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Explore the profile of W Michael Seganish including associated specialties, affiliations and a list of published articles.
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25
Citations
125
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Recent Articles
1.
Chernyak N, Bhagwat B, Naravula S, Chen Y, Solban N, Zhang F, et al.
J Med Chem
. 2024 Sep;
67(18):16222-16234.
PMID: 39235949
Toll-like receptor (TLR) activation converts immunologically inactive tumors into immunologically active tumors by activating tumor residing antigen-presenting cells and recruitment of cytotoxic T lymphocytes. Targeted immune agonists (TIAs) are antibody...
2.
Patel A, Willingham A, Cheng A, Tomazela D, Bowman E, Kofman E, et al.
J Med Chem
. 2024 Aug;
67(17):15756-15779.
PMID: 39172064
Toll-like receptors 7 and 8 are involved in modulating the adaptive and innate immune responses, and their activation has shown promise as a therapeutic strategy in the field of immuno-oncology....
3.
Chen Y, Zhou S, Pradhan K, Chernyak N, Kofman E, Zhang F, et al.
J Immunol Methods
. 2023 Sep;
522:113553.
PMID: 37661047
Targeted immune agonist (TIA) comprising a TLR7 agonist conjugated to tumor-targeting antibodies have been shown to induce potent anti-tumor responses in various preclinical models. However, the clinical proof-of-concept of a...
4.
Mak V, Patel A, Yen R, Hanisak J, Lim Y, Bao J, et al.
J Med Chem
. 2022 Jul;
65(15):10318-10340.
PMID: 35878399
Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP), activation of PKG1α induces smooth muscle relaxation in...
5.
Tawa P, Zhang L, Metwally E, Hou Y, McCoy M, Seganish W, et al.
J Biol Chem
. 2022 Jul;
298(9):102284.
PMID: 35868561
cGMP-dependent protein kinase (PKG) represents a compelling drug target for treatment of cardiovascular diseases. PKG1 is the major effector of beneficial cGMP signaling which is involved in smooth muscle relaxation...
6.
Hou L, Kumar M, Anand P, Chen Y, El-Bizri N, Pickens C, et al.
Sci Rep
. 2022 Mar;
12(1):4337.
PMID: 35288601
Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients. Here, we used previously...
7.
Hanisak J, Soriano A, Adam G, Basso A, Bauman D, Bell D, et al.
ACS Med Chem Lett
. 2021 Aug;
12(8):1275-1282.
PMID: 34413956
PKG1α is a central node in cGMP signaling. Current therapeutics that look to activate this pathway rely on elevation of cGMP levels and subsequent activation of PKG1α. Direct activation of...
8.
Kieffer M, Patel A, Hollingsworth S, Seganish W
Expert Opin Ther Pat
. 2020 Oct;
30(11):825-845.
PMID: 33052748
Introduction: Toll-like receptors 7 and 8 (TLR7 and TLR8) are endosomal immune receptors that initiate an innate immune response and can facilitate activation of the adaptive immune system. Both preclinical...
9.
Hanisak J, Seganish W, McElroy W, Tang H, Zhang R, Tsui H, et al.
Bioorg Med Chem Lett
. 2016 Aug;
26(17):4250-5.
PMID: 27476420
IRAK4 has been identified as potential therapeutic target for inflammatory and autoimmune diseases. Herein we report the identification and initial SAR studies of a new class of pyrazole containing IRAK4...
10.
Seganish W
Expert Opin Ther Pat
. 2016 Jun;
26(8):917-32.
PMID: 27310003
Introduction: IRAK4 is located proximal to TLR/IL-1 receptors, and in preclinical studies, inhibits downstream signaling from these receptors. The development of novel small molecule inhibitors of this kinase has the...