Kristine Devito
Overview
Explore the profile of Kristine Devito including associated specialties, affiliations and a list of published articles.
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11
Citations
156
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Recent Articles
1.
Zhang J, Muise E, Han S, Kutchukian P, Costet P, Zhu Y, et al.
Cell Rep Med
. 2020 Nov;
1(4):100056.
PMID: 33205063
Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues...
2.
Shen X, Smith E, Ai X, McElroy W, Liaw A, Kreamer T, et al.
SLAS Discov
. 2019 Sep;
24(10):978-986.
PMID: 31491347
Interactions between transmembrane receptors and their ligands play important roles in normal biological processes and pathological conditions. However, the binding partners for many transmembrane-like proteins remain elusive. To identify potential...
3.
Walker S, Labroli M, Painter R, Wiltsie J, Sherborne B, Murgolo N, et al.
PLoS One
. 2017 Jul;
12(7):e0180965.
PMID: 28700746
To combat the threat of antibiotic-resistant Gram-negative bacteria, novel agents that circumvent established resistance mechanisms are urgently needed. Our approach was to focus first on identifying bioactive small molecules followed...
4.
Hanisak J, Seganish W, McElroy W, Tang H, Zhang R, Tsui H, et al.
Bioorg Med Chem Lett
. 2016 Aug;
26(17):4250-5.
PMID: 27476420
IRAK4 has been identified as potential therapeutic target for inflammatory and autoimmune diseases. Herein we report the identification and initial SAR studies of a new class of pyrazole containing IRAK4...
5.
Lee S, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, et al.
Sci Transl Med
. 2016 Mar;
8(329):329ra32.
PMID: 26962156
The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current β-lactam antibiotics and created an urgent need for new treatment options. We report an S....
6.
Mann P, McLellan C, Koseoglu S, Si Q, Kuzmin E, Flattery A, et al.
ACS Infect Dis
. 2016 Feb;
1(1):59-72.
PMID: 26878058
Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the...
7.
Seganish W, Fischmann T, Sherborne B, Matasi J, Lavey B, McElroy W, et al.
ACS Med Chem Lett
. 2015 Aug;
6(8):942-7.
PMID: 26288698
We report the identification and synthesis of a series of aminopyrimidin-4-one IRAK4 inhibitors. Through high throughput screening, an aminopyrimidine hit was identified and modified via structure enabled design to generate...
8.
Seganish W, McElroy W, Herr R, Brumfield S, Greenlee W, Harding J, et al.
Bioorg Med Chem Lett
. 2015 Jun;
25(16):3203-7.
PMID: 26115573
IRAK4 plays a key role in TLR/IL-1 signaling. Previous efforts identified a series of aminopyrimidine IRAK4 inhibitors that possess good potency, but modest kinase selectivity. Exploration of substituents at the...
9.
McElroy W, Tan Z, Ho G, Paliwal S, Li G, Seganish W, et al.
ACS Med Chem Lett
. 2015 Jun;
6(6):677-82.
PMID: 26101573
IRAK4 is a critical upstream kinase in the IL-1R/TLR signaling pathway. Inhibition of IRAK4 is hypothesized to be beneficial in the treatment of autoimmune related disorders. A screening campaign identified...
10.
Brumfield S, Matasi J, Tulshian D, Czarniecki M, Greenlee W, Garlisi C, et al.
Bioorg Med Chem Lett
. 2011 Nov;
21(24):7287-90.
PMID: 22078214
Novel P2X(7) antagonists were developed using a purine scaffold. These compounds were potent and selective at the P2X(7) receptor in human and rodent as well as efficacious in rodent pain...