W Froestl
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Explore the profile of W Froestl including associated specialties, affiliations and a list of published articles.
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38
Citations
1684
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Recent Articles
1.
Wieronska J, Kusek M, Tokarski K, Wabno J, Froestl W, Pilc A
Br J Pharmacol
. 2011 Mar;
163(5):1034-47.
PMID: 21371011
Background And Purpose: An important role of GABAergic neurotransmission in schizophrenia was proposed a long time ago, but there is limited data to support this hypothesis. In the present study...
2.
Nowak G, Partyka A, Palucha A, Szewczyk B, Wieronska J, Dybala M, et al.
Br J Pharmacol
. 2006 Aug;
149(5):581-90.
PMID: 16921399
Background And Purpose: A crucial role for the GABAB receptor in depression was proposed several years ago, but there are limited data to support this proposition. Therefore we decided to...
3.
Gibson K, Schor D, Gupta M, Guerand W, Senephansiri H, Burlingame T, et al.
J Neurochem
. 2002 Jun;
81(1):71-9.
PMID: 12067239
Metabolite profiling in succinate semialdehyde dehydrogenase (SSADH; Aldh5a1-/-) deficient mice previously revealed elevated gamma-hydroxybutyrate (GHB) and total GABA in urine and total brain and liver extracts. In this study, we...
4.
Bowery N, Bettler B, Froestl W, GALLAGHER J, Marshall F, Raiteri M, et al.
Pharmacol Rev
. 2002 May;
54(2):247-64.
PMID: 12037141
The gamma-aminobutyric acid(B) (GABA(B)) receptor was first demonstrated on presynaptic terminals where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter release by suppressing neuronal Ca(2+)...
5.
Dobrovitsky V, Pimentel P, Duarte A, Froestl W, Stellar J, Trzcinska M
Neuropharmacology
. 2002 May;
42(5):626-32.
PMID: 11985820
Drugs that alter the function of gamma-aminobutyric acid (GABA) neurotransmission seem to reduce cocaine reinforcement, and as such may be useful in pharmacologically treating cocaine addiction. In the present experiment,...
6.
Giorgetti M, Hotsenpiller G, Froestl W, Wolf M
Neuroscience
. 2002 Feb;
109(3):585-95.
PMID: 11823068
The activity of dopamine neurons in the ventral tegmental area is modulated by excitatory (glutamatergic) and inhibitory (GABAergic) afferents. GABA, released by intrinsic neurons and by projection neurons originating in...
7.
Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, et al.
Mol Pharmacol
. 2001 Oct;
60(5):963-71.
PMID: 11641424
The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of gamma-aminobutyric acid(B) (GABA(B)) receptor function. They potentiate GABA-stimulated guanosine 5'-O-(3-[(35)S]thiotriphosphate) (GTP gamma[(35)S]) binding to membranes...
8.
Hogema B, Gupta M, Senephansiri H, Burlingame T, Taylor M, Jakobs C, et al.
Nat Genet
. 2001 Sep;
29(2):212-6.
PMID: 11544478
Succinate semialdehyde dehydrogenase (ALDH5A1, encoding SSADH deficiency is a defect of 4-aminobutyric acid (GABA) degradation that manifests in humans as 4-hydroxybutyric (gamma-hydroxybutyric, GHB) aciduria. It is characterized by a non-specific...
9.
Schuler V, Luscher C, Blanchet C, Klix N, Sansig G, Klebs K, et al.
Neuron
. 2001 Aug;
31(1):47-58.
PMID: 11498050
GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is...
10.
Froestl W, Bettler B, Bittiger H, Heid J, Kaupmann K, Mickel S, et al.
Farmaco
. 2001 May;
56(1-2):101-5.
PMID: 11347948
Outlined is the rationale behind the syntheses of radioligands [125I]CGP64213 and [125I]CGP71872, which led to the identification of cloned GABA(B) receptors 1a and 1b 17 years after the first pharmacological...