W Froestl
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Explore the profile of W Froestl including associated specialties, affiliations and a list of published articles.
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38
Citations
1684
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Recent Articles
11.
Macey D, Froestl W, Koob G, Markou A
Neuropharmacology
. 2001 Apr;
40(5):676-85.
PMID: 11311895
The present experiments were designed to determine the role of GABA(B) receptor function on brain stimulation reward. Using a discrete-trial current-intensity threshold procedure, dose-effect functions were generated for the GABA(B)...
12.
Ong J, Bexis S, Marino V, Parker D, KERR D, Froestl W
Eur J Pharmacol
. 2001 Mar;
415(2-3):191-5.
PMID: 11274998
In rat neocortical preparations maintained in Mg(2+)-free Krebs medium, baclofen depressed the frequency of spontaneous discharges in a concentration-dependent manner (EC(50) = 6 microM), sensitive to (3-aminopropyl)ethylphosphinic acid (CGP 36216)...
13.
Ong J, Bexis S, Marino V, Parker D, KERR D, Froestl W
Eur J Pharmacol
. 2001 Feb;
412(1):27-37.
PMID: 11166733
In neocortical slices maintained in Mg(2+)-free Krebs medium, the gamma-aminobutyric acid (GABA(B)) receptor agonists baclofen, (3-amino-2(S)-hydroxypropyl)methylphosphinic acid (CGP 44532), and its (R)-enantiomer CGP 44533 depressed the frequency of spontaneous discharges...
14.
Pagano A, Rovelli G, Mosbacher J, Lohmann T, Duthey B, Stauffer D, et al.
J Neurosci
. 2001 Feb;
21(4):1189-202.
PMID: 11160389
Assembly of fully functional GABA(B) receptors requires heteromerization of the GABA(B(1)) and GABA(B(2)) subunits. It is thought that GABA(B(1)) and GABA(B(2)) undergo coiled-coil dimerization in their cytoplasmic C termini and...
15.
Blum W, Aichholz R, Ramstein P, Kuhnol J, Froestl W, Desrayaud S
J Chromatogr B Biomed Sci Appl
. 2000 Nov;
748(2):349-59.
PMID: 11087077
An assay, based on pre-column derivatization and micro-high-performance liquid chromatography-tandem mass spectrometry, was developed for the determination of the GABA(B) agonist CGP 44532 in rat plasma. CGP 44532, a highly...
16.
Galvez T, Prezeau L, Milioti G, Franek M, Joly C, Froestl W, et al.
J Biol Chem
. 2000 Sep;
275(52):41166-74.
PMID: 10986293
The gamma-amino-n-butyric acid type B (GABA(B)) receptor is composed of two subunits, GABA(B)1 and GABA(B)2, belonging to the family 3 heptahelix receptors. These proteins possess two domains, a seven transmembrane...
17.
Froestl W
Pharm Acta Helv
. 2000 May;
74(2-3):247-51.
PMID: 10812965
The ability of trophic factors to regulate developmental neuronal survival and adult nervous system plasticity suggests the use of these molecules to treat neurodegeneration associated with human diseases, such as...
18.
Galvez T, Urwyler S, Prezeau L, Mosbacher J, Joly C, Malitschek B, et al.
Mol Pharmacol
. 2000 Feb;
57(3):419-26.
PMID: 10692480
The gamma-aminobutyric acid (GABA) receptor type B (GABA(B)R) is constituted of at least two homologous proteins, GABA(B)R1 and GABA(B)R2. These proteins share sequence and structural similarity with metabotropic glutamate and...
19.
Ong J, Marino V, Parker D, KERR D, Froestl W
Eur J Pharmacol
. 1999 Dec;
383(2):137-41.
PMID: 10585527
In rat neocortical slices maintained in Mg(2+)-free Krebs medium, the gamma-aminobutyric acid (GABA(B)) receptor agonist baclofen concentration-dependently depressed the frequency of spontaneous discharges (EC(50)=12 microM). This was reversibly antagonised by...
20.
Brebner K, Froestl W, Andrews M, Phelan R, Roberts D
Neuropharmacology
. 1999 Dec;
38(11):1797-804.
PMID: 10587095
Previous self-administration experiments have shown that baclofen, the prototypical GABA(B) agonist, produces an apparent attenuation in the reinforcing effects of cocaine in rats. The present experiments examined the effects of...