H R Olpe
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Explore the profile of H R Olpe including associated specialties, affiliations and a list of published articles.
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103
Citations
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Recent Articles
1.
Gemperle A, Enz A, Pozza M, Luthi A, Olpe H
Neuroscience
. 2003 Mar;
117(3):681-95.
PMID: 12617972
The mode of action of the antipsychotic drugs clozapine, haloperidol and iloperidone was investigated in layer V of prefrontal cortex slices using extracellular field potential, intracellular sharp-electrode as well as...
2.
Bum E, Schmutz M, Meyer C, Rakotonirina A, Bopelet M, Portet C, et al.
J Ethnopharmacol
. 2001 Jun;
76(2):145-50.
PMID: 11390127
The methanolic extract of rhizomes of Cyperus articulatus, a plant used in traditional medicine in Africa and Latin America for many diseases, possesses anticonvulsant activity in mice. This extract protected...
3.
Pozza M, Olpe H, Ofner S, Schoeffel C, Evans R
Eur J Pharmacol
. 1998 Apr;
342(2-3):203-8.
PMID: 9548386
The novel tachykinin receptor antagonist CGP49823 ((2R,4S)-2-benzyl-1-(3,5-dimethylbenzoyl)-4-(quinolin-4-y lmethylamino)piperidine) has been compared with three other selective non-peptide tachykinin NK1 receptor antagonists. The drugs were tested as antagonists of the depolarization of...
4.
Badran S, Schmutz M, Olpe H
Eur J Pharmacol
. 1997 Aug;
333(2-3):135-42.
PMID: 9314026
CGP 56999A ([3-[1-(R)-[(3-cyclohexylmethyl)hydroxyphosphinyl]-2-(S)- hydroxy-propyl] amino]ethyl]-benzoic acid) is a potent GABAB receptor antagonist showing much more pronounced convulsant features in mice than do other previously studied GABAB receptor antagonists. The goal...
5.
LEPRE M, Olpe H, Brugger F
Neuropharmacology
. 1996 Apr;
35(4):511-22.
PMID: 8793915
The effects of substance P (SP) and the selective NK1 receptor agonist [Sar9Met(O2)11] substance P on neonate rat spinal motoneurones were examined using intracellular recordings. Bath-administration of SP (0.1-3 microM)...
6.
Froestl W, Mickel S, Hall R, von Sprecher G, Strub D, Baumann P, et al.
J Med Chem
. 1995 Aug;
38(17):3297-312.
PMID: 7650684
The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABAB receptors. For many years efforts to obtain superior GABAB agonists were unsuccessful. We...
7.
LEPRE M, Olpe H, Evans R, Brugger F
Eur J Pharmacol
. 1994 Jun;
258(1-2):23-31.
PMID: 7523150
The goal of these investigations was to study the role of tachykinin NK2 receptors in neonatal spinal cords using the selective NK2 receptor agonist [beta-Ala8]neurokinin A-(4-10) and the new NK2...
8.
Olpe H, Steinmann M, Greiner K, Pozza M
Naunyn Schmiedebergs Arch Pharmacol
. 1994 May;
349(5):473-7.
PMID: 8065460
The synaptic release of gamma-aminobutyric acid (GABA) is thought to be regulated by presynaptic GABA receptors of the B-type. It was the goal of this study to validate this concept...
9.
McLean M, Schmutz M, Wamil A, Olpe H, Portet C, Feldmann K
Epilepsia
. 1994 Jan;
35 Suppl 3:S5-9.
PMID: 8156978
The antiepileptic drug (AED) oxcarbazepine (OCBZ) and its rapidly formed 10-monohydroxy metabolite (MHD) protect against electroshock-induced tonic hindlimb extension in rodents (ED50 14-21 mg/kg p.o.). Both stereoisomers of MHD also...
10.
Schmutz M, Brugger F, Gentsch C, McLean M, Olpe H
Epilepsia
. 1994 Jan;
35 Suppl 5:S47-50.
PMID: 8039471
Oxcarbazepine (OCBZ, Trileptal) and its main human monohydroxy metabolite (MHD) protected mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5 mg/kg p.o....