Vojtech Hamala
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Explore the profile of Vojtech Hamala including associated specialties, affiliations and a list of published articles.
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9
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20
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Recent Articles
1.
Kurfirt M, cervenkova Stastna L, Dracinsky M, Pohl R, Cisarova I, Sykora J, et al.
J Org Chem
. 2024 Aug;
89(17):11875-11890.
PMID: 39178339
-Acetyllactosamine is a common saccharide motif found in various biologically active glycans. This motif usually works as a backbone for additional modifications and thus significantly influences glycan conformational behavior and...
2.
Kurfirt M, Hamala V, Beranek J, cervenkova Stastna L, cerveny J, Dracinsky M, et al.
Bioorg Chem
. 2024 May;
147:107395.
PMID: 38705105
Fluorination of carbohydrate ligands of lectins is a useful approach to examine their binding profile, improve their metabolic stability and lipophilicity, and convert them into F NMR-active probes. However, monofluorination...
3.
Mullerova M, Hovorkova M, Zavodna T, St Astna L, Krupkova A, Hamala V, et al.
Biomacromolecules
. 2023 Sep;
24(11):4705-4717.
PMID: 37680126
Galectins, the glycan binding proteins, and their respective carbohydrate ligands represent a unique fundamental regulatory network modulating a plethora of biological processes. The advances in galectin-targeted therapy must be based...
4.
Kurfirt M, Dracinsky M, cervenkova Stastna L, Curinova P, Hamala V, Hovorkova M, et al.
Chemistry
. 2021 Jul;
27(51):13040-13051.
PMID: 34216419
Galectins are widely expressed galactose-binding lectins implied, for example, in immune regulation, metastatic spreading, and pathogen recognition. N-Acetyllactosamine (Galβ1-4GlcNAc, LacNAc) and its oligomeric or glycosylated forms are natural ligands of...
5.
Hamala V, cervenkova Stastna L, Kurfirt M, Curinova P, Dracinsky M, Karban J
Beilstein J Org Chem
. 2021 Jun;
17:1086-1095.
PMID: 34093878
Multiple fluorination of glycostructures has emerged as an attractive way of modulating their protein affinity, metabolic stability, and lipophilicity. Here we described the synthesis of a series of mono-, di-...
6.
Hamala V, cervenkova Stastna L, Kurfirt M, Curinova P, Balouch M, Hrstka R, et al.
Org Biomol Chem
. 2021 May;
19(20):4497-4506.
PMID: 33949602
Fully acetylated deoxyfluorinated hexosamine analogues and non-fluorinated 3,4,6-tri-O-acylated N-acetyl-hexosamine hemiacetals have previously been shown to display moderate anti-proliferative activity. We prepared a set of deoxyfluorinated GlcNAc and GalNAc hemiacetals that...
7.
Kurfirt M, Lucie C, Curinova P, Hamala V, Karban J
J Org Chem
. 2021 Mar;
86(7):5073-5090.
PMID: 33705133
The Tn antigen (GalNAcα1-Thr/Ser) is abundantly expressed in many tumors but rarely found in healthy tissues, which makes it an attractive epitope for antitumor immunotherapy. The use of the Tn...
8.
Hamala V, cervenkova Stastna L, Kurfirt M, Curinova P, Dracinsky M, Karban J
Org Biomol Chem
. 2020 Jul;
18(28):5427-5434.
PMID: 32696789
Fluorinated glycans are valuable probes for studying carbohydrate-protein interactions at the atomic level. Glucosamine is a ubiquitous component of glycans, and the stereoselective synthesis of α-linked fluorinated glucosamine is a...
9.
Kurfirt M, cervenkova Stastna L, Dracinsky M, Mullerova M, Hamala V, Curinova P, et al.
J Org Chem
. 2019 May;
84(10):6405-6431.
PMID: 31062975
Control of anomeric stereoselectivity in glycosylation with deoxofluorinated glycosyl donors is critical for assembly of fluorinated oligosaccharides. Here, we report the synthesis of benzylated 3-fluoro and 4-fluoro analogues of phenyl...