Vladimir Y Toshchakov
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Explore the profile of Vladimir Y Toshchakov including associated specialties, affiliations and a list of published articles.
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21
Citations
504
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Recent Articles
1.
Atamas S, Lockatell V, Todd N, Papadimitriou J, Rus V, Lugkey K, et al.
J Pharmacol Exp Ther
. 2025 Feb;
392(1):100008.
PMID: 39893007
Interleukin (IL)-33 has been shown to centrally regulate, among other processes, inflammation and fibrosis. Both intracellular full-length (FLIL33) precursor and extracellular mature cytokine (MIL33) forms exert such regulation, albeit differentially....
2.
Toshchakov V
Biochemistry (Mosc)
. 2024 Jun;
89(5):784-798.
PMID: 38880642
Formation of the transient protein complexes in response to activation of cellular receptors is a common mechanism by which cells respond to external stimuli. This article presents the concept of...
3.
Javmen A, Zou J, Nallar S, Szmacinski H, Lakowicz J, Gewirtz A, et al.
J Immunol
. 2023 Mar;
210(9):1419-1427.
PMID: 36946775
TLR5, which is activated by flagellin, plays an important role in initiating immune response to a broad spectrum of motile bacterial pathogens. TLRs induce intracellular signaling via dimerization of their...
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Richard K, Piepenbrink K, Shirey K, Gopalakrishnan A, Nallar S, Prantner D, et al.
J Exp Med
. 2020 Nov;
218(2).
PMID: 33216117
Two cosegregating single-nucleotide polymorphisms (SNPs) in human TLR4, an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4986791 (T399I), have been associated with LPS hyporesponsiveness and...
6.
Toshchakov V, Neuwald A
Immunogenetics
. 2020 Feb;
72(3):181-203.
PMID: 32002590
Toll-interleukin-1R resistance (TIR) domains are ubiquitously present in all forms of cellular life. They are most commonly found in signaling proteins, as units responsible for signal-dependent formation of protein complexes...
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Javmen A, Szmacinski H, Lakowicz J, Toshchakov V
J Leukoc Biol
. 2019 Oct;
108(6):1697-1706.
PMID: 31642126
TLRs sense a broad range of microbial molecules and initiate antimicrobial immune response. The members of the TLR family use cytoplasmic Toll/interleukin-1R homology (TIR) domain to initiate intracellular signaling. The...
9.
Javmen A, Szmacinski H, Lakowicz J, Toshchakov V
J Immunol
. 2018 Jun;
201(3):995-1006.
PMID: 29914886
Interaction of TLR9 with ligands activates NF-κB, leading to proinflammatory cytokine production. Excessive TLR activation is a pathogenic factor for inflammatory diseases. This study has examined cell-permeating decoy peptides (CPDPs)...
10.
Piao W, Ru L, Toshchakov V
Pathog Dis
. 2016 May;
74(5).
PMID: 27150837
TLR2 heterodimers with TLR1 or TLR6 recognize distinct pathogen-associated molecules such as tri- and di-acylated lipopeptides. The activated TLR2 heterodimers recruit Toll-IL-1R domain- (TIR-) containing adapter proteins, TIRAP and MyD88,...