Eric J Sundberg
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Explore the profile of Eric J Sundberg including associated specialties, affiliations and a list of published articles.
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112
Citations
2503
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Recent Articles
1.
Sastre D, Bournazos S, Du J, Boder E, Edgar J, Azzam T, et al.
Cell
. 2024 Oct;
187(24):6994-7007.e12.
PMID: 39437779
Endo-β-N-acetylglucosaminidases (ENGases) that specifically hydrolyze the Asn297-linked glycan on immunoglobulin G (IgG) antibodies, the major molecular determinant of fragment crystallizable (Fc) γ receptor (FcγR) binding, are exceedingly rare. All previously...
2.
Sastre D, Sultana N, Navarro M, Huliciak M, Du J, Cifuente J, et al.
Nat Commun
. 2024 Jun;
15(1):5123.
PMID: 38879612
Bacteroidales (syn. Bacteroidetes) are prominent members of the human gastrointestinal ecosystem mainly due to their efficient glycan-degrading machinery, organized into gene clusters known as polysaccharide utilization loci (PULs). A single...
3.
Fields J, Gyllenback E, Bogacz M, Obi J, Birkedal G, Sjostrom K, et al.
Cell Rep
. 2024 Apr;
43(5):114099.
PMID: 38636519
Interleukin-1 (IL-1)-family cytokines are potent modulators of inflammation, coordinating a vast array of immunological responses across innate and adaptive immune systems. Dysregulated IL-1-family cytokine signaling, however, is involved in a...
4.
Azzam T, Du J, Flowers M, Ali A, Hunn J, Vijayvargiya N, et al.
Sci Adv
. 2024 Apr;
10(15):eadk8157.
PMID: 38598628
Redesigning protein-protein interfaces is an important tool for developing therapeutic strategies. Interfaces can be redesigned by in silico screening, which allows for efficient sampling of a large protein space before...
5.
Garcia-Alija M, Van Moer B, Sastre D, Azzam T, Du J, Trastoy B, et al.
Biotechnol Adv
. 2023 Jun;
67:108201.
PMID: 37336296
Antibody based drugs, including IgG monoclonal antibodies, are an expanding class of therapeutics widely employed to treat cancer, autoimmune and infectious diseases. IgG antibodies have a conserved N-glycosylation site at...
6.
Du J, Sastre D, Trastoy B, Roberts B, Deredge D, Klontz E, et al.
Methods Mol Biol
. 2023 May;
2674:147-167.
PMID: 37258966
Glycosylation is a common posttranslational modification of proteins and refers to the covalent addition of glycans, chains of polysaccharides, onto proteins producing glycoproteins. The glycans influence the structure, function, and...
7.
Nedeljkovic M, Kreutzberger M, Postel S, Bonsor D, Xing Y, Jacob N, et al.
PLoS Pathog
. 2023 May;
19(5):e1010979.
PMID: 37253071
In its simplest form, bacterial flagellar filaments are composed of flagellin proteins with just two helical inner domains, which together comprise the filament core. Although this minimal filament is sufficient...
8.
Gupta A, Kao K, Yamin R, Oren D, Goldgur Y, Du J, et al.
Nat Commun
. 2023 May;
14(1):2853.
PMID: 37202422
Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and...
9.
ONeal A, Singh N, Rolandelli A, Laukaitis H, Wang X, Shaw D, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2208673120.
PMID: 37155900
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit...
10.
Trastoy B, Du J, Cifuente J, Rudolph L, Garcia-Alija M, Klontz E, et al.
Nat Commun
. 2023 Mar;
14(1):1705.
PMID: 36973249
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Streptococcus pyogenes serotypes secrete two multi-modular endo-β-N-acetylglucosaminidases, EndoS and EndoS2, that specifically...