Leah A Couture
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Explore the profile of Leah A Couture including associated specialties, affiliations and a list of published articles.
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2
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78
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Recent Articles
1.
Couture L, Piao W, Ru L, Vogel S, Toshchakov V
J Biol Chem
. 2012 Jun;
287(29):24641-8.
PMID: 22648407
Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal) is an adapter protein that facilitates recruitment of MyD88 to TLR4 and TLR2 signaling complexes. We previously generated a library of cell-permeating...
2.
Toshchakov V, Szmacinski H, Couture L, Lakowicz J, Vogel S
J Immunol
. 2011 Mar;
186(8):4819-27.
PMID: 21402890
Agonist-induced dimerization of TLR4 Toll/IL-1R (TIR) domains initiates intracellular signaling. Therefore, identification of the TLR4-TIR dimerization interface is one key to the rational design of therapeutics that block TLR4 signaling....