Visvaldas Kairys
Overview
Explore the profile of Visvaldas Kairys including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
46
Citations
535
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0
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Recent Articles
1.
Zebrauskiene D, Sadauskiene E, Dapkunas J, Kairys V, Balciunas J, Konovalovas A, et al.
Clin Epigenetics
. 2024 Jun;
16(1):76.
PMID: 38845031
Tatton-Brown-Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic variants in the DNA methyltransferase DNMT3A gene. Typical TBRS clinical features are overgrowth, intellectual disability, and...
2.
Gedgaudas M, Kaziukonyte P, Kairys V, Mickeviciute A, Zubriene A, Brukstus A, et al.
Eur J Med Chem
. 2024 May;
273:116505.
PMID: 38788300
Human Hsp90 chaperones are implicated in various aspects of cancer. Due to this, Hsp90 has been explored as potential target in cancer treatment. Initial attempts to use Hsp90 inhibitors in...
3.
Kairys V, Baranauskiene L, Kazlauskiene M, Zubriene A, Petrauskas V, Matulis D, et al.
Expert Opin Drug Discov
. 2024 May;
19(6):649-670.
PMID: 38715415
Introduction: Modern drug discovery revolves around designing ligands that target the chosen biomolecule, typically proteins. For this, the evaluation of affinities of putative ligands is crucial. This has given rise...
4.
Breindl M, Spitzer D, Gerasimaite R, Kairys V, Schubert T, Henfling R, et al.
Nucleic Acids Res
. 2023 Nov;
52(1):337-354.
PMID: 38000389
Baz2B is a regulatory subunit of the ATP-dependent chromatin remodeling complexes BRF1 and BRF5, which control access to DNA during DNA-templated processes. Baz2B has been implicated in several diseases and...
5.
Dudkaite V, Kairys V, Bagdziunas G
J Mater Chem B
. 2023 Feb;
11(11):2409-2416.
PMID: 36806466
Long-term stability of enzymes in organic solvents is one of the most challenging problems in modern biotechnology and chemical industries. However, the resistance of enzymes to organic solvents is not...
6.
Tomkuviene M, Meier M, Ikasalaite D, Wildenauer J, Kairys V, Klimasauskas S, et al.
Nucleic Acids Res
. 2022 Jun;
50(11):6549-6561.
PMID: 35648439
Methylation of cytosine to 5-methylcytosine (mC) at CpG sites is a prevalent reversible epigenetic mark in vertebrates established by DNA methyltransferases (MTases); the attached methyl groups can alter local structure...
7.
Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
Balandis B, Simkunas T, Paketuryte-Latve V, Michailoviene V, Mickeviciute A, Manakova E, et al.
Pharmaceuticals (Basel)
. 2022 Apr;
15(4).
PMID: 35455474
A series of novel benzenesulfonamide derivatives were synthesized bearing - β,γ-amino acid or - β-amino acid and thiazole moieties and their binding to the human carbonic anhydrase (CA) isozymes determined....
8.
Goncalves M, Kairys V, Rodrigues J, Tomas H
Biomacromolecules
. 2021 Dec;
23(1):20-33.
PMID: 34870412
Although doxorubicin (DOX) is one of the most used chemotherapeutic drugs due to its efficacy against a wide group of cancer types, it presents severe side effects. As such, intensive...
9.
Baronas D, Dudutiene V, Paketuryte V, Kairys V, Smirnov A, Juozapaitiene V, et al.
Eur Biophys J
. 2021 Jul;
50(7):993-1011.
PMID: 34328515
Zinc-containing metalloenzyme carbonic anhydrase (CA) binds primary sulfonamides with extremely high, up to picomolar, affinity by forming a coordination bond between the negatively charged amino group and the zinc ion...
10.
Kirchhain A, Zubriene A, Kairys V, Vivaldi F, Bonini A, Biagini D, et al.
Bioorg Chem
. 2021 Jul;
115:105155.
PMID: 34303036
Matrix metalloproteinases (MMPs) are an important factor in cancer progression and metastasis, especially gelatinases MMP-2 and MMP-9. A simple methodology for their detection and monitoring is highly desirable. Molecular probes...