Alexey Smirnov
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Explore the profile of Alexey Smirnov including associated specialties, affiliations and a list of published articles.
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64
Citations
1304
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Recent Articles
1.
Vaskevicius A, Trumpickaite G, Parafjanovic E, Manakova E, Mickeviciute A, Gedgaudas M, et al.
Chemistry
. 2025 Feb;
:e202404409.
PMID: 39905940
High affinity and selectivity for intended targets is an important goal of small molecule design in drug discovery, yet balancing molecular flexibility and rigidity remains a challenge. While flexible compounds...
2.
Li S, Ren K, Yan X, Tsyganov A, Mazei Y, Smirnov A, et al.
Imeta
. 2024 Jun;
2(2):e103.
PMID: 38868434
Highly diverse but divergent microeukaryotes dwell in all types of habitats in urban park ecosystems. Extensive microbial migration occurs between both terrestrial and aquatic habitats. Microbial movement is beneficial to...
3.
Paketuryte-Latve V, Smirnov A, Manakova E, Baranauskiene L, Petrauskas V, Zubriene A, et al.
IUCrJ
. 2024 Jun;
11(Pt 4):556-569.
PMID: 38856178
Carbonic anhydrase (CA) was among the first proteins whose X-ray crystal structure was solved to atomic resolution. CA proteins have essentially the same fold and similar active centers that differ...
4.
Li S, Yan X, Abdullah Al M, Ren K, Rensing C, Hu A, et al.
mSystems
. 2024 May;
9(6):e0046924.
PMID: 38767347
Importance: Urban parks, as an important urban greenspace, play essential roles in ecosystem services and are important hotspots for microbes. Microbial diversity is driven by different ecological and evolutionary processes,...
5.
Mesentsev Y, Surkova A, Kamyshatskaya O, Nassonova E, Smirnov A
Eur J Protistol
. 2023 Nov;
91:126030.
PMID: 37922856
We studied a large species of Thecamoeba found in a glass dish with soaked moss and obtained 18s rRNA gene sequence of this organism. Morphologically, the strain was most similar...
6.
Spasov A, Ovchinnikova I, Fedorova O, Titova Y, Babkov D, Kosolapov V, et al.
Molecules
. 2023 Jan;
28(2).
PMID: 36677799
The problem of lung damage originating from excessive inflammation and cytokine release during various types of infections remains relevant and stimulates the search for highly effective and safe drugs. The...
7.
Mesentsev Y, Smirnov A
Eur J Protistol
. 2022 Nov;
86:125941.
PMID: 36442388
A new speciesStenamoeba aeronautan. sp.was isolated from a culture of large thecamoebids during laboratory studies. Our study of this species showed almost complete morphological identity with the well-known speciesStenamoeba stenopodia....
8.
Guanidine Derivatives of Quinazoline-2,4(1,3)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents
Spasov A, Ozerov A, Kosolapov V, Gurova N, Kucheryavenko A, Naumenko L, et al.
Life (Basel)
. 2022 Oct;
12(10).
PMID: 36295082
Quinazolines are a rich source of bioactive compounds. Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a series of quinazoline-2,4(1,3)-diones and quinazoline-4(3)-one guanidine derivatives....
9.
Tekle Y, Wang F, Wood F, Anderson O, Smirnov A
Sci Rep
. 2022 Jul;
12(1):11173.
PMID: 35778543
The supergroup Amoebozoa unites a wide diversity of amoeboid organisms and encompasses enigmatic lineages that have been recalcitrant to modern phylogenetics. Deep divergences, taxonomic placement of some key taxa and...
10.
Spasov A, Kosolapov V, Babkov D, Klochkov V, Sokolova E, Miroshnikov M, et al.
Pharmaceuticals (Basel)
. 2022 May;
15(5).
PMID: 35631365
Acute lung injury remains a challenging clinical condition, necessitating the development of novel, safe and efficient treatments. The prevention of macrophage M1-polarization is a viable venue to tackle excessive inflammation....