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Vishwa Deep Dixit

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Articles 73
Citations 6317
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Recent Articles
1.
Youm Y, Gliniak C, Zhang Y, Dlugos T, Scherer P, Dixit V
Nat Aging . 2025 Feb; PMID: 39972172
Age-related thymic involution precedes aging of all other organs in vertebrates and initiates the process of declining T cell diversity, which leads to eventual immune dysfunction. Whether FGF21, a liver-derived...
2.
Rogina B, Anderson R, LeBrasseur N, Curan S, Yousefzadeh M, Ghosh B, et al.
J Gerontol A Biol Sci Med Sci . 2025 Feb; PMID: 39932386
The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic...
3.
Gonzalez-Hurtado E, Leveau C, Li K, Qu R, Mishra M, Goldberg E, et al.
bioRxiv . 2024 Oct; PMID: 39416197
Age-related inflammation or inflammaging is a key mechanism that increases disease burden and may control lifespan. How adipose tissue macrophages (ATMs) control inflammaging is not well understood in part because...
4.
Kim H, Dixit V
Cell Metab . 2024 Sep; 36(9):1911-1913. PMID: 39232279
Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction. However, the origin of age-related inflammation is incompletely understood. In a recent study published in Nature, Widjaja et ...
5.
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, et al.
bioRxiv . 2024 Aug; PMID: 39149397
Dietary interventions such as caloric restriction (CR) and methionine restriction that prolong lifespan induce the 'browning' of white adipose tissue (WAT), an adaptive metabolic response that increases heat production to...
6.
Ryu S, Spadaro O, Sidorov S, Lee A, Caprio S, Morrison C, et al.
J Clin Invest . 2023 Oct; 133(19). PMID: 37781916
The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous...
7.
Lee A, Sugiura Y, Youm Y, Dlugos T, Maeda R, Coman D, et al.
Res Sq . 2023 Jul; PMID: 37461682
The authors have requested that this preprint be removed from Research Square.
8.
Schuppe A, Liu Y, Gonzalez-Hurtado E, Zhao Y, Jiang X, Ibarraran S, et al.
Chem . 2023 Jul; 8(10):2856-2887. PMID: 37396824
Highly substituted pyridine scaffolds are found in many biologically active natural products and therapeutics. Accordingly, numerous complementary approaches to obtain differentially substituted pyridines have been disclosed. This article delineates the...
9.
Mihaylova M, Chaix A, Delibegovic M, Ramsey J, Bass J, Melkani G, et al.
Cell Metab . 2023 Jul; 35(7):1114-1131. PMID: 37392742
An epidemic of obesity has affected large portions of the world, increasing the risk of developing many different age-associated diseases, including cancer, cardiovascular disease, and diabetes. In contrast with the...
10.
Goldberg E, Letian A, Dlugos T, Leveau C, Dixit V
J Biol Chem . 2023 Feb; 299(3):103005. PMID: 36775129
Aging is accompanied by chronic low-grade inflammation, but the mechanisms that allow this to persist are not well understood. Ketone bodies are alternative fuels produced when glucose is limited and...