Irina Shchukina
Overview
Explore the profile of Irina Shchukina including associated specialties, affiliations and a list of published articles.
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20
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1157
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Recent Articles
1.
Chen X, Firulyova M, Manis M, Herz J, Smirnov I, Aladyeva E, et al.
Nature
. 2024 Oct;
634(8036):E15.
PMID: 39415023
No abstract available.
2.
Bohacova P, Terekhova M, Tsurinov P, Mullins R, Husarcikova K, Shchukina I, et al.
Immunity
. 2024 Sep;
57(10):2362-2379.e10.
PMID: 39321807
Thymic involution is a key factor in human immune aging, leading to reduced thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the...
3.
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, et al.
bioRxiv
. 2024 Aug;
PMID: 39149397
Dietary interventions such as caloric restriction (CR) and methionine restriction that prolong lifespan induce the 'browning' of white adipose tissue (WAT), an adaptive metabolic response that increases heat production to...
4.
Cook M, Shchukina I, Lin C, Bradstreet T, Schwarzkopf E, Jarjour N, et al.
Immunohorizons
. 2023 Nov;
7(11):737-746.
PMID: 37934060
TH17 cells are implicated in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). We previously reported that the transcription factor basic helix-loop-helix family member e40 (BHLHE40) marks cytokine-producing...
5.
Ryu S, Spadaro O, Sidorov S, Lee A, Caprio S, Morrison C, et al.
J Clin Invest
. 2023 Oct;
133(19).
PMID: 37781916
The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous...
6.
Shchukina I, Bohacova P, Artyomov M
Semin Immunol
. 2023 Aug;
70:101818.
PMID: 37611324
T cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to...
7.
Lee A, Sugiura Y, Youm Y, Dlugos T, Maeda R, Coman D, et al.
Res Sq
. 2023 Jul;
PMID: 37461682
The authors have requested that this preprint be removed from Research Square.
8.
Chen X, Firulyova M, Manis M, Herz J, Smirnov I, Aladyeva E, et al.
Nature
. 2023 Mar;
615(7953):668-677.
PMID: 36890231
Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic hallmarks of Alzheimer's disease. The regional progression of...
9.
Koenig A, Shchukina I, Amrute J, Andhey P, Zaitsev K, Lai L, et al.
Nat Cardiovasc Res
. 2022 Aug;
1(3):263-280.
PMID: 35959412
Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression. Through integrated analysis of single-cell and...
10.
Mogilenko D, Shchukina I, Artyomov M
Nat Rev Immunol
. 2021 Nov;
22(8):484-498.
PMID: 34815556
Ageing leads to profound alterations in the immune system and increases susceptibility to some chronic, infectious and autoimmune diseases. In recent years, widespread application of single-cell techniques has enabled substantial...