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Vishnu Chintalgattu

Explore the profile of Vishnu Chintalgattu including associated specialties, affiliations and a list of published articles. Areas
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Articles 22
Citations 567
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Recent Articles
1.
Lee L, Khakoo A, Chintalgattu V
FEBS Open Bio . 2020 Nov; 11(1):207-225. PMID: 33135334
Pericytes (PCs)-mural cells that envelop endothelial cells (ECs) of microvessels-regulate tissue-specific vasculature development as well as maturation and maintenance of endothelial barrier integrity. However, little is known about their tissue-specific...
2.
Ason B, Chen Y, Guo Q, Hoagland K, Chui R, Fielden M, et al.
JCI Insight . 2020 Mar; 5(8). PMID: 32208384
Heart failure (HF) remains a grievous illness with poor prognosis even with optimal care. The apelin receptor (APJ) counteracts the pressor effect of angiotensin II, attenuates ischemic injury, and has...
3.
Lee L, Khakoo A, Chintalgattu V
J Vis Exp . 2019 Sep; (150). PMID: 31475977
Pericytes, perivascular cells of microvessels and capillaries, are known to play a part in angiogenesis, vessel stabilization, and endothelial barrier integrity. However, their tissue-specific functions in the heart are not...
4.
Lee L, Chintalgattu V
Adv Exp Med Biol . 2019 Apr; 1122:187-210. PMID: 30937870
Mural cells known as pericytes envelop the endothelial layer of microvessels throughout the body and have been described to have tissue-specific functions. Cardiac pericytes are abundantly found in the heart,...
5.
Chintalgattu V, Greenberg J, Singh S, Chiueh V, Gilbert A, ONeill J, et al.
Pharmacol Res Perspect . 2018 Nov; 6(6):e00442. PMID: 30459952
Tissue Inhibitor of Metalloproteinase 3 (TIMP3) is a secreted protein that has a great utility to inhibit elevated metalloproteinase (MMP) activity in injured tissues including infarcted cardiac tissue, inflamed vessels,...
6.
Rose B, Yokota T, Chintalgattu V, Ren S, Iruela-Arispe L, Khakoo A, et al.
J Biol Chem . 2017 Jun; 292(31):12787-12800. PMID: 28637870
Stress-induced p38 mitogen-activated protein kinase (MAPK) activity is implicated in pathological remodeling in the heart. For example, constitutive p38 MAPK activation in cardiomyocytes induces pathological features, including myocyte hypertrophy, apoptosis,...
7.
Chintalgattu V, Rees M, Culver J, Goel A, Jiffar T, Zhang J, et al.
Sci Transl Med . 2013 May; 5(187):187ra69. PMID: 23720580
Sunitinib malate is a multitargeted receptor tyrosine kinase inhibitor used in the treatment of human malignancies. A substantial number of sunitinib-treated patients develop cardiac dysfunction, but the mechanism of sunitinib-induced...
8.
Zhang J, Chintalgattu V, Shih T, Ai D, Xia Y, Khakoo A
J Mol Cell Cardiol . 2011 Jun; 51(3):337-46. PMID: 21684288
The platelet derived growth factor receptor (PDGFR) is an important target for novel anti-cancer therapeutics, but agents targeting PDGFR have been associated with cardiotoxicity. Cardiomyocyte PDGFR-β signaling in pressure-overloaded hearts...
9.
Chintalgattu V, Khakoo A
Clin Adv Hematol Oncol . 2010 Apr; 8(2):133-5. PMID: 20386535
No abstract available.
10.
Chintalgattu V, Ai D, Langley R, Zhang J, Bankson J, Shih T, et al.
J Clin Invest . 2010 Jan; 120(2):472-84. PMID: 20071776
PDGFR is an important target for novel anticancer therapeutics because it is overexpressed in a wide variety of malignancies. Recently, however, several anticancer drugs that inhibit PDGFR signaling have been...