Vishal C Birar
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Explore the profile of Vishal C Birar including associated specialties, affiliations and a list of published articles.
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8
Citations
60
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Recent Articles
1.
Zhou Y, Li C, Wu R, Yin H, Liu G, Meng H, et al.
Mol Pharm
. 2024 Nov;
21(12):6433-6443.
PMID: 39504500
Ischemic stroke is a devastating disease that causes neuronal death, neuroinflammation, and other cerebral damage. However, effective therapeutic strategies for ischemic stroke are still lacking. Histone deacetylase 6 (HDAC6) has...
2.
Bai P, Liu Y, Yang L, Ding W, Mondal P, Sang N, et al.
J Med Chem
. 2023 Nov;
66(23):16075-16090.
PMID: 37972387
Recent studies have shown that the epigenetic protein histone deacetylase 11 (HDAC11) is highly expressed in the brain and critically modulates neuroimmune functions, making it a potential therapeutic target for...
3.
Liu G, Mondal P, Sang N, Li Z, Ding W, Yang L, et al.
Eur J Med Chem
. 2023 Apr;
254:115327.
PMID: 37098307
Targeting histone deacetylase 6 (HDAC6) has emerged as a promising therapeutic approach for anti-inflammation and related biological pathways, including inflammatory events associated with the brain. In this study, in order...
4.
Birar V, Zaid G, Blagg B
Tetrahedron Lett
. 2021 Oct;
73.
PMID: 34672489
Herbal medicine is used as a complement to modern medicine for the treatment of human diseases suchas cancer, inflammation, and diabetes. Nutraceutical components in foods such as vanillin produceantioxidant and...
5.
Birar V, Sheerin A, Ostler E, Faragher R
Biogerontology
. 2020 Aug;
21(6):817-826.
PMID: 32793997
Resveratrol alters the cytokinetics of mammalian cell populations in a dose dependent manner. Concentrations above 25-50 µM typically trigger growth arrest, senescence and/or apoptosis in multiple different cell types. In...
6.
Birar V, Gelis I, Zuo A, Blagg B
Bioorg Med Chem Lett
. 2020 Jul;
30(16):127303.
PMID: 32631523
Identification of a ligand binding site represents the starting point for a structure-based drug development program. Lack of a binding site hampers the development of improved ligands that modulate the...
7.
Latorre E, Birar V, Sheerin A, Jeynes J, Hooper A, Dawe H, et al.
BMC Cell Biol
. 2017 Oct;
18(1):31.
PMID: 29041897
Background: Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with...
8.
Birar V, Sheerin A, Milkovicova J, Faragher R, Ostler E
Chem Cent J
. 2015 May;
9:26.
PMID: 26023318
Background: Compounds based on trans-1,2-diphenylethene are the subject of intense interest both for their optical properties and as potential leads for drug discovery, as a consequence of their anticancer, anti-inflammatory...