Vincent Poitout
Overview
Explore the profile of Vincent Poitout including associated specialties, affiliations and a list of published articles.
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Articles
89
Citations
3752
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Recent Articles
1.
Cantley J, Poitout V, Hull-Meichle R
J Endocrinol
. 2023 May;
258(3).
PMID: 37194667
The year 2023 marks 100 years since publication of the first report of a hyperglycemic factor in pancreatic extracts which C P Kimball and John R Murlin named glucagon (from...
2.
Lacombe J, Guo K, Bonneau J, Faubert D, Gioanni F, Vivoli A, et al.
Cell Rep
. 2023 May;
42(5):112500.
PMID: 37171959
Vitamin K is a micronutrient necessary for γ-carboxylation of glutamic acids. This post-translational modification occurs in the endoplasmic reticulum (ER) and affects secreted proteins. Recent clinical studies implicate vitamin K...
3.
Vivoli A, Ghislain J, Filali-Mouhim A, Angeles Z, Castell A, Sladek R, et al.
Diabetes
. 2022 Oct;
72(1):45-58.
PMID: 36191509
The functional mass of insulin-secreting pancreatic β-cells expands to maintain glucose homeostasis in the face of nutrient excess, in part via replication of existing β-cells. Type 2 diabetes appears when...
4.
Castell A, Goubault C, Ethier M, Fergusson G, Tremblay C, Baltz M, et al.
JCI Insight
. 2022 Sep;
7(21).
PMID: 36107617
Puberty is associated with transient insulin resistance that normally recedes at the end of puberty; however, in overweight children, insulin resistance persists, leading to an increased risk of type 2...
5.
Castell A, Vivoli A, Tippetts T, Frayne I, Angeles Z, Moulle V, et al.
Diabetes
. 2022 Mar;
71(6):1218-1232.
PMID: 35287172
Fatty acid (FA) signaling contributes to β-cell mass expansion in response to nutrient excess, but the underlying mechanisms are poorly understood. In the presence of elevated glucose, FA metabolism is...
6.
Linnemann A, Poitout V, Rutter G
Front Endocrinol (Lausanne)
. 2022 Jan;
12:832519.
PMID: 35046906
No abstract available.
7.
Jouvet N, Bouyakdan K, Campbell S, Baldwin C, Townsend S, Gannon M, et al.
Diabetes
. 2021 Oct;
70(12):2850-2859.
PMID: 34610983
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects...
8.
Maachi H, Ghislain J, Tremblay C, Poitout V
Sci Rep
. 2021 May;
11(1):11283.
PMID: 34050242
The potential to treat diabetes by increasing beta-cell mass is driving a major effort to identify beta-cell mitogens. Demonstration of mitogen activity in human beta cells is frequently performed in...
9.
Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice
Croze M, Guillaume A, Ethier M, Fergusson G, Tremblay C, Campbell S, et al.
Endocrinology
. 2021 Feb;
162(3).
PMID: 33543237
The free fatty-acid receptors FFAR1 (GPR40) and FFAR4 (GPR120) are implicated in the regulation of insulin secretion and insulin sensitivity, respectively. Although GPR120 and GPR40 share similar ligands, few studies...
10.
Ghislain J, Poitout V
Nat Rev Endocrinol
. 2021 Jan;
17(3):162-175.
PMID: 33495605
Therapeutic approaches to the treatment of type 2 diabetes mellitus that are designed to increase insulin secretion either directly target β-cells or indirectly target gastrointestinal enteroendocrine cells (EECs), which release...