Thierry Alquier
Overview
Explore the profile of Thierry Alquier including associated specialties, affiliations and a list of published articles.
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52
Citations
3004
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Recent Articles
1.
Lau D, Tobin S, Pribiag H, Nakajima S, Fisette A, Matthys D, et al.
Nat Commun
. 2024 Dec;
15(1):10652.
PMID: 39681558
α/β-hydrolase domain 6 (ABHD6) is a lipase linked to physiological functions affecting energy metabolism. Brain ABHD6 degrades 2-arachidonoylglycerol and thereby modifies cannabinoid receptor signalling. However, its functional role within mesoaccumbens...
2.
Manceau R, Majeur D, Cherian C, Miller C, Wat L, Fisher J, et al.
bioRxiv
. 2024 Sep;
PMID: 39345476
Lipids are essential for neuron development and physiology. Yet, the central hubs that coordinate lipid supply and demand in neurons remain unclear. Here, we combine invertebrate and vertebrate models to...
3.
Robb J, Boisjoly F, Machuca-Parra A, Coursan A, Manceau R, Majeur D, et al.
Brain Behav Immun
. 2024 Sep;
123:315-333.
PMID: 39326768
Lipid droplets (LD) are triglyceride storing organelles that have emerged as an important component of cellular inflammatory responses. LD lipolysis via adipose triglyceride lipase (ATGL), the enzyme that catalyses the...
4.
Nakajima S, Demers G, Machuca-Parra A, Pour Z, Bairamian D, Bouyakdan K, et al.
J Neuroinflammation
. 2023 Dec;
20(1):302.
PMID: 38111048
G protein-coupled receptor 120 (GPR120, Ffar4) is a sensor for long-chain fatty acids including omega-3 polyunsaturated fatty acids (n-3 PUFAs) known for beneficial effects on inflammation, metabolism, and mood. GPR120...
5.
Beland-Millar A, Kirby A, Truong Y, Ouellette J, Yandiev S, Bouyakdan K, et al.
Cell Rep
. 2023 May;
42(5):112485.
PMID: 37149866
Neurovascular abnormalities in mouse models of 16p11.2 deletion autism syndrome are reminiscent of alterations reported in murine models of glucose transporter deficiency, including reduced brain angiogenesis and behavioral alterations. Yet,...
6.
Bouyakdan K, Manceau R, Robb J, Rodaros D, Fulton S, Alquier T
J Neuroendocrinol
. 2022 Dec;
34(12):e13218.
PMID: 36471907
Acyl-CoA binding protein (ACBP), also known as diazepam binding inhibitor (DBI), has recently emerged as a hypothalamic and brainstem gliopeptide regulating energy balance. Previous work has shown that the ACBP-derived...
7.
Jouvet N, Bouyakdan K, Campbell S, Baldwin C, Townsend S, Gannon M, et al.
Diabetes
. 2021 Oct;
70(12):2850-2859.
PMID: 34610983
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects...
8.
Alquier T, Christian-Hinman C, Alfonso J, Faergeman N
Trends Endocrinol Metab
. 2021 Sep;
32(11):890-903.
PMID: 34565656
Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABA receptor, and was thus termed diazepam binding...
9.
Diaz-Marin R, Crespo-Garcia S, Wilson A, Buscarlet M, Dejda A, Fournier F, et al.
Sci Rep
. 2021 Aug;
11(1):15767.
PMID: 34344941
The beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as heat. While immune cells, such as tissue-resident...
10.
Menzies C, Naz S, Patten D, Alquier T, Bennett B, Lacoste B
eNeuro
. 2021 Apr;
8(2).
PMID: 33820803
Prevalence of metabolic disturbances is higher among individuals with neurodevelopmental disorders (NDDs), yet this association has been largely overlooked. Investigation into human disease remains challenging, as a complete pathophysiological understanding...