Vincent Hascall
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Explore the profile of Vincent Hascall including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
527
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Recent Articles
1.
Wang A, Wang A, Hascall V
J Allergy Infect Dis
. 2024 Apr;
4(1):16-23.
PMID: 38618493
Many diabetic complications, such as renal and cardiovascular disease, share a common association with extensive and chronic inflammation due to infiltration by activated leukocytes that originate from the bone marrow...
2.
Wang A, Wang A, Hascall V
Front Biosci (Landmark Ed)
. 2024 Feb;
29(2):71.
PMID: 38420831
The abnormal intermediate glucose metabolic pathways induced by elevated intracellular glucose levels during hyperglycemia often establish the metabolic abnormality that leads to cellular and structural changes in development and to...
3.
Nguyen L, Lin X, Verma S, Puri S, Hascall V, Gesteira T, et al.
Transl Vis Sci Technol
. 2023 Apr;
12(4):13.
PMID: 37052911
Purpose: Hyaluronan (HA) exists in two forms, high molecular weight HA (HMWHA) and low molecular weight HA (LMWHA), which have distinct physiological functions. Therefore it is imperative to know the...
4.
Mutoji K, Sun M, Nash A, Puri S, Hascall V, Coulson-Thomas V
BMC Immunol
. 2021 Aug;
22(1):52.
PMID: 34348643
Background: Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We...
5.
Midgley A, Woods E, Jenkins R, Brown C, Khalid U, Chavez R, et al.
Am J Pathol
. 2020 Mar;
190(6):1236-1255.
PMID: 32201263
Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactive;...
6.
Wolk A, Hatipoglu D, Cutler A, Ali M, Bell L, Qi J, et al.
Cells
. 2020 Mar;
9(3).
PMID: 32143276
Sorsby's fundus dystrophy (SFD) is an inherited blinding disorder caused by mutations in the tissue inhibitor of metalloproteinase-3 () gene. The SFD pathology of macular degeneration with subretinal deposits and...
7.
Abbadi A, Loftis J, Wang A, Yu M, Wang Y, Shakya S, et al.
J Biol Chem
. 2020 Feb;
295(15):4849-4857.
PMID: 32107314
Monocytes are rapidly recruited to sites of diabetic complications and differentiate into macrophages. Previously, we showed that rat kidney mesangial cells dividing during hyperglycemic stress abnormally synthesize hyaluronan (HA) in...
8.
Tseng V, Ni K, Allawzi A, Prohaska C, Hernandez-Lagunas L, Elajaili H, et al.
Sci Rep
. 2020 Jan;
10(1):280.
PMID: 31937874
Chronic hypoxia leads to pathologic remodeling of the pulmonary vasculature and pulmonary hypertension (PH). The antioxidant enzyme extracellular superoxide dismutase (SOD3) protects against hypoxia-induced PH. Hyaluronan (HA), a ubiquitous glycosaminoglycan...
9.
Midgley A, Oltean S, Hascall V, Woods E, Steadman R, Phillips A, et al.
Sci Signal
. 2017 Nov;
10(506).
PMID: 29162741
The cell surface protein CD44 is involved in diverse physiological processes, and its aberrant function is linked to various pathologies such as cancer, immune dysregulation, and fibrosis. The diversity of...
10.
Zahreddine H, Culjkovic-Kraljacic B, Emond A, Pettersson F, Midura R, Lauer M, et al.
Elife
. 2017 Nov;
6.
PMID: 29111978
The microenvironment provides a functional substratum supporting tumour growth. Hyaluronan (HA) is a major component of this structure. While the role of HA in malignancy is well-defined, the mechanisms driving...