Vijaya L Manthati
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Explore the profile of Vijaya L Manthati including associated specialties, affiliations and a list of published articles.
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14
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518
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Recent Articles
1.
Dakarapu R, Errabelli R, Manthati V, Adebesin A, Barma D, Barma D, et al.
Bioorg Med Chem Lett
. 2019 Aug;
29(19):126616.
PMID: 31439380
19-Hydroxyeicosatetraenoic acid (19-HETE, 1), a metabolically and chemically labile cytochrome P450 eicosanoid, has diverse biological activities including antagonism of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE, 2). A SAR study was conducted...
2.
Hoff U, Bubalo G, Fechner M, Blum M, Zhu Y, Pohlmann A, et al.
Acta Physiol (Oxf)
. 2019 May;
227(2):e13297.
PMID: 31077555
Aim: Imbalances in cytochrome P450 (CYP)-dependent eicosanoid formation may play a central role in ischemic acute kidney injury (AKI). We reported previously that inhibition of 20-hydroxyeicosatetraenoic acid (20-HETE) action ameliorated...
3.
Khan A, Falck J, Manthati V, Campbell W, Imig J
Front Pharmacol
. 2014 Oct;
5:216.
PMID: 25295006
Epoxyeicosatrienoic acids (EETs) contribute to blood pressure regulation leading to the concept that EETs can be therapeutically targeted for hypertension and the associated end organ damage. In the present study,...
4.
Falck J, Koduru S, Mohapatra S, Manne R, Atcha K, Atcha R, et al.
J Med Chem
. 2014 Aug;
57(16):6965-72.
PMID: 25119815
The cytochrome P450 eicosanoid 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a powerful endogenous autacoid that has been ascribed an impressive array of physiologic functions including regulation of blood pressure. Because 14,15-EET is...
5.
Gangadhariah M, Luther J, Garcia V, Paueksakon P, Zhang M, Hayward S, et al.
J Am Soc Nephrol
. 2014 Jul;
26(3):597-610.
PMID: 25071086
In the kidney, 20-hydroxyeicosatetraenoic acid (20-HETE) is a primary cytochrome P450 4 (Cyp4)-derived eicosanoid that enhances vasoconstriction of renal vessels and induces hypertension, renal tubular cell hypertrophy, and podocyte apoptosis....
6.
Panigrahy D, Kalish B, Huang S, Bielenberg D, Le H, Yang J, et al.
Proc Natl Acad Sci U S A
. 2013 Jul;
110(33):13528-33.
PMID: 23898174
Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450 epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic effects on cells, the role of these epoxyeicosanoids in normal organ and...
7.
Tunctan B, Korkmaz B, Sari A, Kacan M, Unsal D, Serin M, et al.
Nitric Oxide
. 2013 May;
33:18-41.
PMID: 23684565
We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine (5,14-HEDGE), prevents vascular hyporeactivity, hypotension, tachycardia, and inflammation in rats treated with lipopolysaccharide (LPS) and mortality...
8.
Wu C, Mei S, Cheng J, Ding Y, Weidenhammer A, Garcia V, et al.
J Am Soc Nephrol
. 2013 May;
24(8):1288-96.
PMID: 23641057
Although the mechanism underlying the effect of androgen on BP and cardiovascular disease is not well understood, recent studies suggest that 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a primary cytochrome P450 4 (Cyp4)-derived...
9.
Lukaszewicz K, Falck J, Manthati V, Lombard J
Clin Sci (Lond)
. 2012 Sep;
124(5):333-42.
PMID: 22938512
The present study tested the hypothesis that the Dahl SS (salt-sensitive) rat has vascular dysfunction due, in part, to the up-regulation of the CYP4A/20-HETE (cytochrome P450 ω-hydroxylase 4A)/20-hydroxyeicosatetraenoic acid) system....
10.
Panigrahy D, Edin M, Lee C, Huang S, Bielenberg D, Butterfield C, et al.
J Clin Invest
. 2011 Dec;
122(1):178-91.
PMID: 22182838
Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a...