John R Falck
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Explore the profile of John R Falck including associated specialties, affiliations and a list of published articles.
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Articles
357
Citations
9483
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Recent Articles
1.
Capdevila J, Falck J, Adebesin A
Prostaglandins Other Lipid Mediat
. 2025 Jan;
177:106967.
PMID: 39889333
Epoxyeicosatrienoic acids (EETs) are a class of cytochrome P450 (P450) arachidonic acid (AA) metabolites with diverse biological activities including anti-hypertensive, vasodilatory, angiogenic, and anti-inflammatory properties. While their functions as autocrine...
2.
Wu H, Adebesin A, Falck J, Xu X, Chen J, Masi T, et al.
Biochem Biophys Res Commun
. 2024 Sep;
734:150660.
PMID: 39260207
No abstract available.
3.
Ghoshal K, Luther J, Pakala S, Chetyrkin S, Falck J, Zent R, et al.
Diabetes
. 2024 May;
73(8):1229-1243.
PMID: 38743615
Article Highlights:
4.
Kranrod J, Darwesh A, Bassiouni W, Huang A, Fang L, Korodimas J, et al.
J Cardiovasc Pharmacol
. 2024 Jan;
83(1):105-115.
PMID: 38180457
Mounting evidence suggests that cytochrome P450 epoxygenase-derived metabolites of docosahexaenoic acid, called epoxydocosapentaenoic acids (EDPs), limit mitochondrial damage after cardiac injury. In particular, the 19,20-EDP regioisomer has demonstrated potent cardioprotective...
5.
Pascale J, Wolf A, Kadish Y, Diegisser D, Kulaprathazhe M, Yemane D, et al.
Adv Pharmacol
. 2023 May;
97:229-255.
PMID: 37236760
Vascular function is dynamically regulated and dependent on a bevy of cell types and factors that work in concert across the vasculature. The vasoactive eicosanoid, 20-Hydroxyeicosatetraenoic acid (20-HETE) is a...
6.
Lukaszewicz K, Falck J, Lombard J
Antioxidants (Basel)
. 2023 Apr;
12(4).
PMID: 37107157
In Dahl salt-sensitive (SS) rats, impaired vascular relaxation can be restored by: () minipump infusion of a low (sub-pressor) dose of angiotensin II (ANG II) to restore physiological levels of...
7.
Cardenas S, Colombero C, Cruz M, Mormandi E, Adebesin A, Falck J, et al.
Mol Cell Endocrinol
. 2022 Oct;
559:111784.
PMID: 36202260
The androgen receptor (AR) and AR-driven genes are crucial in normal and neoplastic prostate tissue. Previous results showed a link between 20-hydroxyeicosatetraenoic acid (20-HETE) production and AR-driven prostate cancer (PCa)...
8.
Munnuri S, Falck J
J Am Chem Soc
. 2022 Sep;
144(39):17989-17998.
PMID: 36161865
Iminodirhodium reactive intermediates generated from -tosyloximes using Rh(esp) in CHCl at rt were exploited for an agile trichotomy of challenging transformations: (1) remote using an exceptionally broad diversity of inorganic...
9.
Anugu R, Falck J
Chem Sci
. 2022 Jun;
13(17):4821-4827.
PMID: 35655896
Benzylic/allylic alcohols are converted site-selective C(sp)-C(sp) cleavage to value-added nitrogenous motifs, , anilines and/or nitriles as well as N-heterocycles, utilizing commercial hydroxylamine--sulfonic acid (HOSA) and EtN in an operationally simple,...
10.
Tunctan B, Senol S, Temiz-Resitoglu M, Yilmaz D, Guden D, Bahceli O, et al.
J Cardiovasc Pharmacol
. 2022 Mar;
80(2):276-293.
PMID: 35323151
The orphan receptor, G protein-coupled receptor (GPR) 75, which has been shown to mediate various effects of 20-hydroxyeicosatetraenoic acid (20-HETE), is considered as a therapeutic target in the treatment of...