William B Campbell
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Explore the profile of William B Campbell including associated specialties, affiliations and a list of published articles.
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139
Citations
2943
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Recent Articles
1.
Editorial: Cytochromes P450, their modulators and metabolites in cardiovascular function and disease
Adebesin A, Roman R, Campbell W, Seubert J, Totah R
Front Pharmacol
. 2024 Dec;
15:1531166.
PMID: 39697552
No abstract available.
2.
Kriska T, Natarajan J, Herrnreiter A, Park S, Pfister S, Thomas M, et al.
Am J Physiol Cell Physiol
. 2024 May;
327(1):C151-C167.
PMID: 38798270
Substance P (SP) is released from sensory nerves in the arteries and heart. It activates neurokinin-1 receptors (NK1Rs) causing vasodilation, immune modulation, and adverse cardiac remodeling. The hypothesis was tested:...
3.
Kriska T, Herrnreiter A, Pfister S, Adebesin A, Falck J, Campbell W
Hypertension
. 2021 Nov;
79(1):104-114.
PMID: 34784723
12/15-LO (12/15-lipoxygenase), encoded by gene, metabolizes arachidonic acid to 12(S)-HETE (12-hydroxyeicosatetraenoic acid). Macrophages are the major source of 12/15-LO among immune cells, and 12/15-LO plays a crucial role in development...
4.
McCaffrey S, Lim G, Bullock M, Kasparian A, Clifton-Bligh R, Campbell W, et al.
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33371319
Histamine is a basic amine stored in mast cells, with its release capable of activating one of four histamine receptors. The histamine 3 receptor (HR) is known to be cardioprotective...
5.
Neckar J, Hye Khan M, Gross G, Cyprova M, Hrdlicka J, Kvasilova A, et al.
Clin Sci (Lond)
. 2019 Apr;
133(8):939-951.
PMID: 30979784
Epoxyeicosatrienoic acids (EETs) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart...
6.
Park S, Herrnreiter A, Pfister S, Gauthier K, Falck B, Falck J, et al.
J Biol Chem
. 2018 May;
293(27):10675-10691.
PMID: 29777058
Endothelium-derived epoxyeicosatrienoic acids (EETs) have numerous vascular activities mediated by G protein-coupled receptors. Long-chain free fatty acids and EETs activate GPR40, prompting us to investigate the role of GPR40 in...
7.
Kriska T, Thomas M, Falck J, Campbell W
J Lipid Res
. 2018 Feb;
59(4):615-624.
PMID: 29472381
Polarization of macrophages to proinflammatory M1 and to antiinflammatory alternatively activated M2 states has physiological implications in the development of experimental hypertension and other pathological conditions. 12/15-Lipoxygenase (12/15-LO) and its...
8.
Shah A, Kriska T, Gauthier K, Falck J, Campbell W
Endocrinology
. 2017 Nov;
159(1):217-226.
PMID: 29140411
Angiotensin II (Ang II) and adrenocorticotropic hormone (ACTH) regulate adrenal vascular tone in vitro through endothelial and zona glomerulosa cell-derived mediators. The role of these mediators in regulating adrenal blood...
9.
Kopf P, Park S, Herrnreiter A, Krause C, Roques B, Campbell W
Endocrinology
. 2017 Nov;
159(1):238-247.
PMID: 29088382
Hyperaldosteronism is associated with hypertension, cardiac hypertrophy, and congestive heart failure. Steroidogenic factors facilitate aldosterone secretion by increasing adrenal blood flow. Angiotensin (Ang) II decreases adrenal vascular tone through release...
10.
Campbell W, Imig J, Schmitz J, Falck J
J Cardiovasc Pharmacol
. 2017 Sep;
70(4):211-224.
PMID: 28937442
Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory...